By Tyler Gagan BME 281 Section 2

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Presentation transcript:

By Tyler Gagan BME 281 Section 2 Tissue Engineering By Tyler Gagan BME 281 Section 2

Overview Isolation of patients cell Creation of synthetic scaffold Proliferation of cells onto scaffold

History 1970’s: (John F. Burke) First skin substitute. Purified shark collagen, long sugar molecule. 1970’s-1980’s First successful human derived skin substitute procedure (Howard Green, Harvard Medical)

Modern Application Repair of damaged cells Replacing non-existent cells Artificial organ parts/entire organs

Limitations Very long cell adhesion time. Thick tissues need vascularization. Proper cell environment is tough to mimic. 100-200 micrometers thick (diffusion limit for Oxygen)

Future Increased growth rate and adhesion rate Growth of entirely biocompatible organs. Stocked tissue databases.

Sources "Research Current Research Programs." Pittsburgh Tissue Engineering Initiative. N.p., n.d. Web. 08 Oct. 2012. <http://www.ptei.org/interior.php?pageID=274>. "Tissue Engineering and Regenerative Medicine: History, Progress, and Challenges." - Annual Review of Chemical and Biomolecular Engineering, 2(1):403. N.p., n.d. Web. 08 Oct. 2012. <http://www.annualreviews.org/doi/full/10.1146/annurev-chembioeng-061010-114257>. "Tissue Engineering." Tissue Engineering. N.p., n.d. Web. 08 Oct. 2012. <http://www.atp.nist.gov/focus/tissue.htm>. "Tissue-Engineering." Tissue-Engineering. N.p., n.d. Web. 08 Oct. 2012. <http://tissue-engineering.net/>.