A Untreated mM maphos, 48h 20 mM maphos, 48h 50 mM maphos, 48hh B

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A Untreated 10 mM maphos, 48h 20 mM maphos, 48h 50 mM maphos, 48hh B Suppl. Figure 1. Maphosphamide is cytotoxic for AB1-HA tumor cells. (A) AB1-HA cells were treated with different doses of maphosphamide for 48 h and visually analyzed. Maphosphamide is the active metabolite of CY and is used because CY requires in vivo activation. (B) Quantitation of maphosphamide toxicity using MTT viability assay.

Control CD25 depleted Suppl. Figure 2. Effects of CD25 (PC61) depletion. PBL were stained for CD4 and CD25 3 days after injection of saline (left panel) or PC61 anti-CD25 antibody (right panel).