by Jeffrey R. Martens, and Craig H. Gelband

Slides:

Advertisements

Similar presentations

Sarcolemmal Ca2+-entry through L-type Ca2+ channels controls the profile of Ca2+- activated Cl− current in canine ventricular myocytes Balázs Horváth,

Advertisements

by Michael D. Elliott, Ajoy Kapoor, Michele A. Parker, Dixon B

Regulation of Neuronal Nitric Oxide Synthase in Rat Adrenal Medulla

by Hiroyuki Morita, and Issei Komuro

Effect of γ-aminobutyric acid and nattokinase-enriched fermented beans on the blood pressure of spontaneously hypertensive and normotensive Wistar–Kyoto.

Carotid Artery Mechanical Properties of Dahl Salt-Sensitive Rats

Chronic Hypoxia Suppresses Pregnancy-Induced Upregulation of Large-Conductance Ca2+-Activated K+ Channel Activity in Uterine ArteriesNovelty and Significance.

by Javier Navarro-Antolín, Konstantin L

by Bing S. Huang, Detlev Ganten, and Frans H. H. Leenen

Inefficient Reprogramming of Fibroblasts into Cardiomyocytes Using Gata4, Mef2c, and Tbx5Novelty and Significance by Jenny X. Chen, Markus Krane, Marcus-Andre.

Therapeutic Targeting of Mitochondrial Superoxide in Hypertension

Altered Angiotensinogen Amino Acid Sequence and Plasma Angiotensin II Levels in Genetically Hypertensive Rats by Norbert Hübner, Reinhold Kreutz, Saori.

Neuregulins Regulate Cardiac Parasympathetic Activity

Dynamic Modulation of Interendothelial Gap Junctional Communication by 11,12-Epoxyeicosatrienoic Acid by Rüdiger Popp, Ralf P. Brandes, Gregor Ott, Rudi.

by Yanping Liu, Ken Terata, Nancy J. Rusch, and David D. Gutterman

Correction for vol. 41, p. 156 Hypertension Volume 43(2):e9-e9

A Cardiac Sodium Channel Mutation Cosegregates With a Rare Connexin40 Genotype in Familial Atrial Standstill by W. Antoinette Groenewegen, Mehran Firouzi,

Impaired Renal Vasodilation and Urinary cGMP Excretion in Dahl Salt-Sensitive Rats by Shlomoh Simchon, William Manger, Gabriele Blumberg, Jeffrey Brensilver,

by Satoshi Kokura, Robert E. Wolf, Toshikazu Yoshikawa, D

by Xianming Lin, Mark Crye, and Richard D. Veenstra

by Holly R. Middlekauff, Andrea Doering, and James N. Weiss

Pulse Pressure and Resistance Artery Structure in the Elderly

Volume 118, Issue 2, Pages (February 2000)

Potassium Channels and Proliferation of Vascular Smooth Muscle Cells

The Calcium Paradoxon of Renin Release

Madhu Prasad, Jeffrey B. Matthews, Xue D. He, Hamid I. Akbarali

External Tetraethylammonium As a Molecular Caliper for Sensing the Shape of the Outer Vestibule of Potassium Channels Frank Bretschneider, Anja Wrisch,

Use of intermediate/small conductance calcium-activated potassium-channel activator for endothelial protection Qin Yang, MD, PhD, Jun-Hao Huang, MPhil,

Molecular Determinants of U-Type Inactivation in Kv2.1 Channels

Volume 115, Issue 3, Pages (September 1998)

Sodium Entry during Action Potentials of Mammalian Neurons: Incomplete Inactivation and Reduced Metabolic Efficiency in Fast-Spiking Neurons Brett C.

Volume 10, Issue 1, Pages (January 2013)

Endocannabinoids Control the Induction of Cerebellar LTD

Volume 118, Issue 2, Pages (February 2000)

M.J. Mason, A.K. Simpson, M.P. Mahaut-Smith, H.P.C. Robinson

Volume 122, Issue 4, Pages (April 2002)

Klaus Bielefeldt, Noriyuki Ozaki, Gerald F. Gebhart Gastroenterology

Volume 42, Issue 4, Pages (May 2004)

Volume 11, Issue 3, Pages (February 2001)

Down-regulation of L-type calcium channels in inflamed circular smooth muscle cells of the canine colon Xiaorong Liu, Nancy J. Rusch, Joerg Striessnig,

Christopher A. Ward, Hongqun Liu, Samuel S. Lee Gastroenterology

Volume 65, Issue 1, Pages (January 2004)

Jill S Cameron, Loic Lhuillier, Priya Subramony, Stuart E Dryer Neuron

Thermal Mechanisms of Millimeter Wave Stimulation of Excitable Cells

Volume 11, Issue 1, Pages (January 2014)

Depolarizing cardiac arrest and endothelium-derived hyperpolarizing factor–mediated hyperpolarization and relaxation in coronary arteries: The effect.

Involvement of ion channels in human eosinophil respiratory burst

Effect of motilin and erythromycin on calcium-activated potassium channels in rabbit colonic myocytes Gang Lu, Michael G. Sarr, Joseph H. Szurszewski

Brian Chu, Marten Postma, Roger C. Hardie Biophysical Journal

Volume 110, Issue 5, Pages (March 2016)

Respiratory Rhythm Neuron Volume 34, Issue 5, Pages (May 2002)

X.-x. Dong, D. Ehrenstein, K.H. Iwasa Biophysical Journal

Volume 97, Issue 6, Pages e3 (March 2018)

Volume 117, Issue 6, Pages (December 1999)

Cholecalciferol treatment restores the relaxant responses of spontaneously hypertensive rat arteries to bradykinin Antonio C.R Borges, Teresa Feres,

Calcitonin gene–related peptide inhibits angiotensin II–mediated vasoconstriction in human radial arteries: Role of the Kir channel Anthony Zulli, PhD,

A Shaker K+ Channel with a Miniature Engineered Voltage Sensor

Even pore-localizing missense variants at highly conserved sites in KCNQ1-encoded Kv7.1 channels may have wild-type function and not cause type 1 long.

Volume 87, Issue 5, Pages (November 2004)

Susan K. Fellner, William J. Arendshorst Kidney International

Jeffrey S Diamond, Dwight E Bergles, Craig E Jahr Neuron

Jan D. Huizinga, Yaohui Zhu, Jing Ye, Areles Molleman Gastroenterology

Volume 67, Issue 1, Pages (January 2005)

Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and exocytosis. Involvement of IRS-1 in L-783,281–stimulated increases in [Ca2+]i and.

Attenuation of glucose-, ex-4–, and GIP-induced increases in NSCC current in β-cells from TRPM2-KO mice. Attenuation of glucose-, ex-4–, and GIP-induced.

Dileep K. Rohra, T Yamakuni, Y Ohizumi

A, Representative examples of Ca currents elicited by repetitive 3 Hz depolarizing voltage steps to 0 mV from a holding potential of −40 mV from a CA1.

Byung-Chang Suh, Karina Leal, Bertil Hille Neuron

EMT alters activation of AKT and serum-independent proliferation.

Volume 101, Issue 11, Pages (December 2011)

Presentation transcript:

by Jeffrey R. Martens, and Craig H. Gelband Alterations in Rat Interlobar Artery Membrane Potential and K+ Channels in Genetic and Nongenetic Hypertension by Jeffrey R. Martens, and Craig H. Gelband Circulation Research Volume 79(2):295-301 August 1, 1996 Copyright © American Heart Association, Inc. All rights reserved.

Isolation of K(v) and K(Ca) current in WKY and SHR interlobar artery cells. Isolation of K(v) and K(Ca) current in WKY and SHR interlobar artery cells. A, In the presence of 4-AP (10 mmol/L) and niflumic acid (100 μmol/L), SHR K(Ca) current was significantly greater than WKY K(Ca) current. Similar results were obtained in seven cells. Voltage-ramp and -step depolarizations are shown at the top and bottom of the panel, respectively. B, In the presence of charybdotoxin (100 nmol/L) and niflumic acid (100 μmol/L), WKY K(v) current was significantly greater than SHR K(v) current. Similar results were obtained in seven cells. Voltage-ramp and -step depolarizations are shown at the top and bottom of the panel, respectively. These two cells had similar membrane capacitances (WKY, 26 pF; SHR, 27 pF). Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:295-301 Copyright © American Heart Association, Inc. All rights reserved.

Isolation of K(v) current in SD and DOCA hypertensive interlobar artery cells. Isolation of K(v) current in SD and DOCA hypertensive interlobar artery cells. In the presence of charybdotoxin (100 nmol/L) and niflumic acid (100 μmol/L), SD K(v) current was significantly greater than DOCA hypertensive K(v) current during step depolarizations (holding potential, −80 mV; test potential, −20 mV to 80 mV; 20-mV steps) and ramp depolarizations (−80 to 80 mV, 4 seconds). The membrane capacitances of the two cells were similar (SD, 30 pF; DOCA, 29 pF). Similar results were obtained in seven cells. Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:295-301 Copyright © American Heart Association, Inc. All rights reserved.

Isolation of K(Ca) current in SD and DOCA hypertensive interlobar artery cells. Isolation of K(Ca) current in SD and DOCA hypertensive interlobar artery cells. In the presence of 4-AP (10 mmol/L) and niflumic acid (100 μmol/L), DOCA hypertensive K(Ca) current was significantly greater than SD K(Ca) current during step depolarizations (A; holding potential, −80 mV; test potential, −20 to 70 mV; 10-mV steps) and ramp depolarizations (B, −80 to 80 mV, 4 seconds). These two cells had similar membrane capacitances (SD, 29 pF; DOCA, 30 pF). Similar results were obtained in seven cells. Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:295-301 Copyright © American Heart Association, Inc. All rights reserved.

Mean current-voltage relationships for K(v) and K(Ca) currents in SD and DOCA hypertensive cells. Mean current-voltage relationships for K(v) and K(Ca) currents in SD and DOCA hypertensive cells. DOCA hypertensive K(v) current (A) and K(Ca) current (B) are significantly altered compared with control (n=7). Error bars are the same size as the symbol and therefore are not visible. Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:295-301 Copyright © American Heart Association, Inc. All rights reserved.

Basal and Ang II–stimulated [Ca2+]i. Basal and Ang II–stimulated [Ca2+]i. Both basal and Ang II–stimulated [Ca2+]i are significantly different from control (n=7, P<.05). Jeffrey R. Martens, and Craig H. Gelband Circ Res. 1996;79:295-301 Copyright © American Heart Association, Inc. All rights reserved.