Justin C. Williams, Paul J. Campagnola Neuron

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Wearable Second Harmonic Generation Imaging: The Sarcomeric Bridge to the Clinic Justin C. Williams, Paul J. Campagnola Neuron Volume 88, Issue 6, Pages 1067-1069 (December 2015) DOI: 10.1016/j.neuron.2015.12.009 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Description and Demonstration of Wearable SHG Microscope (A) An alert subject wears the microscope during imaging of the tibialis anterior muscle. Two optical fibers that deliver laser illumination (blue sheath) and collect SHG signals (red sheath) provide flexible optical coupling to a mobile cart. (Inset) Light source, photodetector, and computer reside on the cart. (B) Cross-section of the CAD diagram of the microscope, showing the housing, optical components, and electrical line used to excite motor neurons via the microendoscope. (Inset) Magnified view of the probe tip and the muscle fiber orientation during imaging. (C and D) SHG line-scans of the biceps brachii of the relaxed, affected, and unaffected limb, respectively, of a poststroke subject. Scale bars are 10 μm (vertical) and 100 ms (horizontal). Adapted from Sanchez et al. (2015). Neuron 2015 88, 1067-1069DOI: (10.1016/j.neuron.2015.12.009) Copyright © 2015 Elsevier Inc. Terms and Conditions