by William I. Rosenblum, and Brandon Wormley

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Presentation transcript:

by William I. Rosenblum, and Brandon Wormley Selective Depression of Endothelium-Dependent Dilations During Cerebral Ischemia by William I. Rosenblum, and Brandon Wormley Stroke Volume 26(10):1877-1882 October 1, 1995 Copyright © American Heart Association, Inc. All rights reserved.

Bar graph shows a very large and significant impairment in response to ACh in 10 mice; response was tested before and again beginning 10 minutes after bilateral carotid artery occlusion (P<.01, ANOVA). Bar graph shows a very large and significant impairment in response to ACh in 10 mice; response was tested before and again beginning 10 minutes after bilateral carotid artery occlusion (P<.01, ANOVA). William I. Rosenblum, and Brandon Wormley Stroke. 1995;26:1877-1882 Copyright © American Heart Association, Inc. All rights reserved.

Bar graph shows that bilateral carotid occlusion for 10 minutes failed to diminish response of pial arterioles to SNP (n=10 mice). Bar graph shows that bilateral carotid occlusion for 10 minutes failed to diminish response of pial arterioles to SNP (n=10 mice). William I. Rosenblum, and Brandon Wormley Stroke. 1995;26:1877-1882 Copyright © American Heart Association, Inc. All rights reserved.

Bar graph shows significant (P< Bar graph shows significant (P<.01, ANOVA) reduction in response to bradykinin (Bk) observed in 10 mice when response beginning after 10 minutes of bilateral carotid occlusion was compared with preischemic response. Bar graph shows significant (P<.01, ANOVA) reduction in response to bradykinin (Bk) observed in 10 mice when response beginning after 10 minutes of bilateral carotid occlusion was compared with preischemic response. William I. Rosenblum, and Brandon Wormley Stroke. 1995;26:1877-1882 Copyright © American Heart Association, Inc. All rights reserved.

Bar graph shows responses to calcium ionophore A-23187 tested in two groups of 10 mice each. Bar graph shows responses to calcium ionophore A-23187 tested in two groups of 10 mice each. In one group testing occurred after sham ligation of carotid arteries. In the other group testing began 10 minutes after actual ligation. Response in the ligated mice was greatly diminished (P<.01, ANOVA). William I. Rosenblum, and Brandon Wormley Stroke. 1995;26:1877-1882 Copyright © American Heart Association, Inc. All rights reserved.