Genes Within the MHC Region Have a Dramatic Influence on Radiation-Enhanced Atherosclerosis in MiceClinical Perspective by Weibin Shi, Zhimin Zhang, Mei-Hua.

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Genes Within the MHC Region Have a Dramatic Influence on Radiation-Enhanced Atherosclerosis in MiceClinical Perspective by Weibin Shi, Zhimin Zhang, Mei-Hua Chen, John F. Angle, and Alan H. Matsumoto Circ Genom Precis Med Volume 3(5):409-413 October 19, 2010 Copyright © American Heart Association, Inc. All rights reserved.

Atherosclerotic lesions in the aortic root of female B6.apoE−/− and C3.SW.apoE−/− mice transplanted after lethal irradiation with donor bone marrow from either B6.apoE−/− or C3.SW.apoE−/− mice. Atherosclerotic lesions in the aortic root of female B6.apoE−/− and C3.SW.apoE−/− mice transplanted after lethal irradiation with donor bone marrow from either B6.apoE−/− or C3.SW.apoE−/− mice. Four groups of experiments were performed: C3.SW.apoE−/−→B6.apoE−/− (n=16), B6.apoE−/− →B6.apoE−/− (n=14), B6.apoE−/−→C3.SW.apoE−/− (n=23), and C3.SW.apoE−/−→C3.SW.apoE−/− (n=20). After transplantation, mice were fed a chow diet for 16 weeks. Values are expressed as means±SEM. *P<0.05 versus B6.apoE−/− recipients. Weibin Shi et al. Circ Cardiovasc Genet. 2010;3:409-413 Copyright © American Heart Association, Inc. All rights reserved.

Plasma cholesterol and triglyceride levels in female B6 Plasma cholesterol and triglyceride levels in female B6.apoE−/− (n=14) and C3.SW.apoE−/− mice (n=20) reconstituted with syngeneic bone marrow. Plasma cholesterol and triglyceride levels in female B6.apoE−/− (n=14) and C3.SW.apoE−/− mice (n=20) reconstituted with syngeneic bone marrow. Blood was collected from overnight-fasted mice at 16 weeks after transplantation. Values are means±SEM. *P<0.05 versus B6.apoE−/− mice. Weibin Shi et al. Circ Cardiovasc Genet. 2010;3:409-413 Copyright © American Heart Association, Inc. All rights reserved.

Comparison between female C3. SW. apoE−/− (n=20) and C3H Comparison between female C3.SW.apoE−/− (n=20) and C3H.apoE−/− mice (n=12) reconstituted with syngeneic bone marrow in atherosclerotic lesion size at 16 weeks after transplantation. Comparison between female C3.SW.apoE−/− (n=20) and C3H.apoE−/− mice (n=12) reconstituted with syngeneic bone marrow in atherosclerotic lesion size at 16 weeks after transplantation. Values are expressed as means±SEM. *P<0.05 versus C3H.apoE−/− mice. Weibin Shi et al. Circ Cardiovasc Genet. 2010;3:409-413 Copyright © American Heart Association, Inc. All rights reserved.

Atherosclerotic lesion size in the aortic root of female C3. SW Atherosclerotic lesion size in the aortic root of female C3.SW.apoE−/− mice with (n=10) or without irradiation (n=5). Atherosclerotic lesion size in the aortic root of female C3.SW.apoE−/− mice with (n=10) or without irradiation (n=5). Mice were irradiated with a single dose of 0 or 600 rads. After irradiation, mice were fed the chow diet for 16 weeks. Values are means±SEM. *P<0.05 versus nonirradiated mice. Weibin Shi et al. Circ Cardiovasc Genet. 2010;3:409-413 Copyright © American Heart Association, Inc. All rights reserved.

Plasma cholesterol and triglyceride levels in female C3. SW Plasma cholesterol and triglyceride levels in female C3.SW.apoE−/− mice with (n=9) or without irradiation (n=10). Plasma cholesterol and triglyceride levels in female C3.SW.apoE−/− mice with (n=9) or without irradiation (n=10). Values are means±SEM. Radiation with a single dose of 600 rads had no significant influence on plasma lipid levels of the mice. Weibin Shi et al. Circ Cardiovasc Genet. 2010;3:409-413 Copyright © American Heart Association, Inc. All rights reserved.

Atherosclerotic lesion size in the aortic root of wild-type female C3 Atherosclerotic lesion size in the aortic root of wild-type female C3.SW or C3H mice. Atherosclerotic lesion size in the aortic root of wild-type female C3.SW or C3H mice. Mice were lethally irradiated and transplanted with bone marrow from apoE−/− or apoE+/+ mice. Four weeks after transplantation, mice were started on an atherogenic diet and maintained on the diet for 12 weeks. One group of C3.SW mice did not receive irradiation and transplantation but were challenged with the atherogenic diet. Values are means± SEM. *P<0.05 versus C3H mice. C3.SW (n=9): wild-type C3.SW mice receiving no irradiation and no transplantation; C3.SW→C3.SW (n=9): lethally irradiated wild-type C3.SW mice were reconstituted with bone marrow from wild-type C3.SW mice; C3.apoE−/−→C3.SW (n=15): lethally irradiated wild-type C3.SW mice reconstituted with bone marrow from C3.SW.apoE−/− mice; C3H→C3H (n=15): lethally irradiated wild-type C3H/HeJ mice reconstituted with bone marrow from wild-type C3H/HeJ mice; C3H.apoE−/−→C3H (n=14): lethally irradiated wild-type C3H/HeJ mice were reconstituted with marrow from C3H.apoE−/− mice. Weibin Shi et al. Circ Cardiovasc Genet. 2010;3:409-413 Copyright © American Heart Association, Inc. All rights reserved.