Optimizing Aminoglycoside Use

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Optimizing Aminoglycoside Use William A. Craig, MD Critical Care Clinics Volume 27, Issue 1, Pages 107-121 (January 2011) DOI: 10.1016/j.ccc.2010.11.006 Copyright © 2011 Terms and Conditions

Fig. 1 The time course of killing and regrowth of Pseudomonas aeruginosa in thighs of neutropenic mice following 3 doses of tobramycin (TOB) in normal mice (left panel) and amikacin in mice with renal impairment (right panel). T>MIC, time above minimum inhibitory concentration. Critical Care Clinics 2011 27, 107-121DOI: (10.1016/j.ccc.2010.11.006) Copyright © 2011 Terms and Conditions

Fig. 2 The relationship between different PK?PD indices and change in the number of bacteria in the thighs of neutropenic mice. The R2 value reflects the coefficient of determination. CFU, colony-forming units. Critical Care Clinics 2011 27, 107-121DOI: (10.1016/j.ccc.2010.11.006) Copyright © 2011 Terms and Conditions

Fig. 3 The relationship between efficacy of aminoglycoside therapy in patients with gram-negative bacillary infections and the peak/MIC ratio. Critical Care Clinics 2011 27, 107-121DOI: (10.1016/j.ccc.2010.11.006) Copyright © 2011 Terms and Conditions