Reduction in Lipopolysaccharide-Induced Thrombocytopenia by Triflavin in a Rat Model of Septicemia by Joen-Rong Sheu, Wei-Chung Hung, Ching-Hsiang Wu,

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Date of download: 5/30/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Endothelial Cell Hypertrophy Induced by Vascular.

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Reduction in Lipopolysaccharide-Induced Thrombocytopenia by Triflavin in a Rat Model of Septicemia by Joen-Rong Sheu, Wei-Chung Hung, Ching-Hsiang Wu, Ming-Chieh Ma, Ya-Chen Kan, Chien-Huang Lin, Ming-Shyan Lin, Hsiung-Ning Luk, and Mao-Hsiung Yen Circulation Volume 99(23):3056-3062 June 15, 1999 Copyright © American Heart Association, Inc. All rights reserved.

Effect of RGD-containing peptides on the release of TxB2 from plasma in LPS-treated rats at various times after the start of LPS injection. Effect of RGD-containing peptides on the release of TxB2 from plasma in LPS-treated rats at various times after the start of LPS injection. The rats received normal saline (○), LPS alone (4 mg/kg, IV bolus; ▿), or pretreatment with triflavin (500 μg/kg; □) or GRGDS (20 mg/kg, ⋄)followed by addition of LPS. Data are presented as mean±SEM (n=8). *P<0.05; **P<0.01, significant difference compared with LPS-treated rats. Joen-Rong Sheu et al. Circulation. 1999;99:3056-3062 Copyright © American Heart Association, Inc. All rights reserved.

Effect of RGD-containing peptides on the accumulation of 5-HT in the blood and organ tissues 4 hours after the start of LPS injection in rats. Effect of RGD-containing peptides on the accumulation of 5-HT in the blood and organ tissues 4 hours after the start of LPS injection in rats. The rats received normal saline (□), LPS alone (4 mg/kg IV bolus; ▧), or pretreatment with triflavin (500 μg/kg; ▨) or GRGDS (20 mg/kg; ▩) followed by addition of LPS. Data are presented as mean±SEM (n=8) *P<0.01; **P<0.001, significant difference compared with normal saline–treated rats. #P<0.05; ##P<0.01, significant difference compared with LPS-treated rats. Joen-Rong Sheu et al. Circulation. 1999;99:3056-3062 Copyright © American Heart Association, Inc. All rights reserved.

Transmission electron micrographs of liver sections in normal saline–treated (A), LPS-treated (4 mg/kg IV bolus) (B and C), and pretreatment with triflavin (500 μg/kg) followed by addition of LPS (D) in rats. Transmission electron micrographs of liver sections in normal saline–treated (A), LPS-treated (4 mg/kg IV bolus) (B and C), and pretreatment with triflavin (500 μg/kg) followed by addition of LPS (D) in rats. A, Kupffer cell (arrowhead) is seen in the hepatic sinusoidal spaces of normal liver (magnification ×3750). B, Undegranulation of platelets (arrow) interacts with the cell processes of an endothelial cell (arrowhead) in the Disse spaces (magnification ×20 250). C, Platelet (arrowhead) is localized in a Disse space and interacts with the cell processes of a Kupffer cell (arrow) (magnification ×20 800). D, No platelets are seen in either the sinusoidal spaces (**) or Disse spaces (*) (magnification ×5250). Joen-Rong Sheu et al. Circulation. 1999;99:3056-3062 Copyright © American Heart Association, Inc. All rights reserved.

Effect of triflavin on scanning electron micrograph of endothelium in normal saline–treated and LPS-treated rat thoracic aorta. Effect of triflavin on scanning electron micrograph of endothelium in normal saline–treated and LPS-treated rat thoracic aorta. Rats received (A) normal saline (control), (B) LPS (4 mg/kg IV bolus) alone, or (C) pretreatment with triflavin (500 μg/kg) followed by addition of LPS. Arrow indicates damaged endothelium; arrowhead indicates aggregating platelets. All photographs are in the same field and are a representative example of 5 similar experiments. Joen-Rong Sheu et al. Circulation. 1999;99:3056-3062 Copyright © American Heart Association, Inc. All rights reserved.

Effect of RGD-containing peptides on collagen-activated platelet adhesion to fibronectin (Fn), vitronectin (Vn), von Willebrand factor (vWF), and laminin (Ln) substrates. Effect of RGD-containing peptides on collagen-activated platelet adhesion to fibronectin (Fn), vitronectin (Vn), von Willebrand factor (vWF), and laminin (Ln) substrates. Platelets were washed, labeled, and activated with collagen (10 μg/mL) as described in Methods. □, GRGES (2 mmol/L); ▧, triflavin (1 μmol/L); and ▨, GRGDS (2 mmol/L). The extent of inhibition of adhesion is expressed as a percentage of platelets initially added to the plates. Data are presented as mean±SEM (n=6). *P<0.01; **P<0.001, significant difference compared with GRGES. Joen-Rong Sheu et al. Circulation. 1999;99:3056-3062 Copyright © American Heart Association, Inc. All rights reserved.

Effect of triflavin and PDTC in plasma nitrate concentration in LPS-treated rats at various times after the start of LPS injection. Effect of triflavin and PDTC in plasma nitrate concentration in LPS-treated rats at various times after the start of LPS injection. Rats received normal saline (○), LPS (4 mg/kg IV bolus; ▿) alone, or pretreatment with triflavin (500 μg/kg; □) or PDTC (10 mg/kg; ⋄) followed by addition of LPS. Data are presented as mean±SEM (n=6). *P<0.05; **P<0.01, significant difference compared with LPS-treated rats. Joen-Rong Sheu et al. Circulation. 1999;99:3056-3062 Copyright © American Heart Association, Inc. All rights reserved.