Establishment of human IgE system in severe combined immunodeficient mice with peripheral blood mononuclear cells from asthmatic children Bor-Luen Chiang,

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Establishment of human IgE system in severe combined immunodeficient mice with peripheral blood mononuclear cells from asthmatic children Bor-Luen Chiang, MD, PhD, Chen-Cheng Chou, MD, Han-Jen Ding, BS, Mao-Sheng Huang, BS, Jong-Min Chen, MD, Kue-Hsiung Hsieh, MD Journal of Allergy and Clinical Immunology Volume 95, Issue 1, Pages 69-76 (January 1995) DOI: 10.1016/S0091-6749(95)70154-0 Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 1 IgG, IgA, and IgM levels in SCID mice reconstituted with PBMCs from asthmatic children (A) and normal adults (B). The patterns were similar between the two groups. Human immunoglobulins peaked at 6 weeks after reconstitution and declined thereafter. Journal of Allergy and Clinical Immunology 1995 95, 69-76DOI: (10.1016/S0091-6749(95)70154-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 2 Human IgE could be detected in mice sera 3 weeks after reconstitution with PBMCs from asthmatic children, and the level peaked at 9 weeks (n = 21). In contrast, only a trace of IgE could be detected in sera of mice reconstituted with PBMCs from normal adults (n = 6). Journal of Allergy and Clinical Immunology 1995 95, 69-76DOI: (10.1016/S0091-6749(95)70154-0) Copyright © 1995 Mosby, Inc. Terms and Conditions

FIG. 3 Serum levels (diluted 1:2) of mite-specific IgE antibodies in human sera of PBMC donors (112.9 ± 17.8 EU/ml, n = 6) in SCID-PBL-hu mice immunized with mite–aluminum hydroxide (14.1 ± 4.5 EU/ml, n = 6), with mite antigens in PBS (6.9 ± 2.5, n = 7), and with PBS only (1.5 ± 0.4 EU/ml, n = 5). Journal of Allergy and Clinical Immunology 1995 95, 69-76DOI: (10.1016/S0091-6749(95)70154-0) Copyright © 1995 Mosby, Inc. Terms and Conditions