Uncontrolled Wnt signaling causes leukemia

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Uncontrolled Wnt signaling causes leukemia by Frank J. T. Staal Blood Volume 109(12):5073-5074 June 15, 2007 ©2007 by American Society of Hematology

Wnt and Notch signaling during murine T-cell development in the thymus. Wnt and Notch signaling during murine T-cell development in the thymus. The roles of Wnt and Notch signaling in both normal and malignant development are indicated. The stages in which constitutively activated forms of molecules in the Wnt or Notch pathways lead to malignant transformation are still somewhat speculative. Data from various sources combining human and mouse models are summarized.1–3 Illustration by A. Y. Chen. Frank J. T. Staal Blood 2007;109:5073-5074 ©2007 by American Society of Hematology