by Edward E. Morrisey Circulation Research Volume 109(6):

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Not Too Large and Not Too Small–Just the Right Size: A Hippo-Sized Heart by Edward E. Morrisey Circulation Research Volume 109(6):614-615 September 2, 2011 Copyright © American Heart Association, Inc. All rights reserved.

The Hippo pathway component Salvador (Salv) interacts with the Mst1/2 homologues of the Hippo protein, and this complex regulates phosphorylation of the Lats tumor suppressor gene. The Hippo pathway component Salvador (Salv) interacts with the Mst1/2 homologues of the Hippo protein, and this complex regulates phosphorylation of the Lats tumor suppressor gene. Lats in turn regulates phosphorylation of YAP. Phosphorylated YAP is excluded from the nucleus. Nonphosphorylated YAP interacts with both TEAD transcription factors and β-catenin, providing an important connection between the Hippo and Wnt/β-catenin pathways that controls cardiomyocyte number and proliferation. Edward E. Morrisey Circ Res. 2011;109:614-615 Copyright © American Heart Association, Inc. All rights reserved.