Enteric pathogen bacteria

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Presentation transcript:

Enteric pathogen bacteria Enterobacteriaceae Gram negative Exotoxin  enterotoxin Endotoxin in cell walls(LPS)

Antigens 3 major groups of antigens: Somatic O Lipopolysacharides Capsular K antigens / Vi antigen Flagellar H proteins

Virulence Factors Enterotoxin Capsule Antigenic phase variation Exotoxin production Adhesion factors Intracellular survival and multiplication  protecting from antibiotic&immune reaction

Antimicrobial resistance  exposure to antibiotic Resistance to serum killing  capsule

Endotoxin. Lipid A component of LPS Release upon cell death & lysis Endotoxin Mediated Toxicity: Fever Leukopenia Activation of complement Thrombocytopenia

- Disseminated Intravascular coagulation - Decreased peripheral circulation - Shock - Death Exotoxin production Enterotoxin Shiga&shiga like toxin cytotoxic,enterotoxic Hemolysins

Desease due to Enterobacteriaceae Intestinal Infections Pathogenic processesinvasive 2. Extra intestinal Infections Enteric commensals opportunistic pathogens

Enteritis : non bloody diarrhea Septicemia Enteric fever Asymptomatic carriage/chronic carriage Shigellosis: pus&bloody in the stoolmucosal ulceration.

Pathogenesis Bacteremia- Septicemia Ingestion of bacteriasmall intestine mesenteric lymph node  bacteremia RES system(multiplication)septicemia and BileGall bladder:. Cholecystitis . Carriage stage  Inflamation&ulceration of Peyer’s patches

2. Infection is limited to the mucosa and sub mucosa of the intestine

Clinically Significant Nonfermentative Gram Negative Bacilli Pseudomonas Acinetobacter Virulence Factors Assosiated with Pseudomonas: . Pili . Exotoxin . Capsule . Enzymes . Endotoxin

Infections Opportunistic pathogen Bacteremia Endocarditis Pulmonary Infections Ear Infection Burn wound Infection UTI Eye Infections ,ect