Statistical colorings of 1H NMR estimates of biochemical variables.

Slides:

Advertisements

Similar presentations

A Novel Bayesian Approach for Uncovering Potential Spectroscopic Counterparts for Clinical Variables in 1 H NMR Metabonomic Applications Aki Vehtari 1.

Advertisements

Date of download: 6/26/2016 Copyright © The American College of Cardiology. All rights reserved. From: Plasma triglycerides and type III hyperlipidemia.

Microtubule perturbations affect pathway variability η2(P) and transmitted signal P at or upstream of the Ste5 recruitment step Microtubule perturbations.

GFP‐Sed5p localization defect in sgt2Δ.

Growth rate‐dependent gene expression under glucose limitation.

Abundance of proteins matching selected subcellular locations and functions in CaCo‐2 cells. Abundance of proteins matching selected subcellular locations.

Simulation of oxygen and substrate demands for ammonia detoxification.

CRISPR knockdown of the mrdAB operon increases cell width at high repression strengths CRISPR knockdown of the mrdAB operon increases cell width at high.

Summary of clinical and metabolic characteristics.

Central carbon metabolic flux patterns under glucose‐limited and glucose‐excess conditions. Central carbon metabolic flux patterns under glucose‐limited.

Melting behavior of proteins identified in the Escherichia coli meltome and their properties Melting behavior of proteins identified in the Escherichia.

Overview of the experimental setting.

DNA damage induces complex signal activation dynamics across many signaling pathways. DNA damage induces complex signal activation dynamics across many.

Most promoters preserve their relative activity levels across conditions. Most promoters preserve their relative activity levels across conditions. (A)

Sensitivity of RNA‐seq.

Analysis of in silico flux changes along the exponential growth phase: (A) In silico flux changes from 24 to 36 h, from 36 to 48 h, and from 48 to 60 h.

Illustration of the reactions and metabolites obtained from random sampling. Illustration of the reactions and metabolites obtained from random sampling.

Activity flow of the mTOR signaling network.

Heatmaps of the gene mutation distributions in oncogene‐signaling blocks for six representative cancer types. Heatmaps of the gene mutation distributions.

Predicted and measured double‐ring formation.

Simple Cysts in Donor Kidney Contribute to Reduced Allograft Function

Validation of the CCE associations by mass spectrometry.

(C–F) Complete interaction networks (representing both baits and preys) for selected groups of baits. (C–F) Complete interaction networks (representing.

Relationship between clinical data and latent factors

Structure of in‐frame deletions.

In silico models and experimental assessment of programmed synthetic biochemical circuits In silico models and experimental assessment of programmed synthetic.

Luminex phosphorylation measurements are reproducible and have broad dynamic range Individual difference in insulin‐induced phosphorylation of ERK measured.

The human STRIPAK complex associates with RASF3 and MST1/2

Correlating protein to mRNA and proteins per mRNA ratios

Characterization of promoters relative to pAGA1

Heat maps showing global relative growth phenotype and comparison between measured and predicted values. Heat maps showing global relative growth phenotype.

Alignment time for Clustal Omega (red), MAFFT (blue), MUSCLE (green) and Kalign (purple) against the number of sequences of HomFam test sets. Alignment.

Validation of some ePTL candidates.

The limiting, degrading entity hypothesis

Effect of the loss of Kar4 on the induction of various promoters

Patient organoids respond more diverse to drugs and with lower therapeutic potential than 2D cultured patient cells Patient organoids respond more diverse.

Optimality principles in adaptive evolution.

CRISPR knockdown can be multiplexed to modulate expression of two genes without cross‐talk CRISPR knockdown can be multiplexed to modulate expression of.

Chemical inhibitors of microtubule function attenuate signal but do not affect pathway variability Chemical inhibitors of microtubule function attenuate.

DeathPro dyes Hoechst and PI do not affect organoid growth and drug responses DeathPro dyes Hoechst and PI do not affect organoid growth and drug responses.

Francis Crick's central dogma of biology revolves around the transcription of mRNA from DNA, the translation of proteins from mRNA, and the degradation.

Evaluation of assay performance with positive and negative binary reference sets Evaluation of assay performance with positive and negative binary reference.

Allele‐specific expression at single‐cell resolution

Two‐way unsupervised uncentered unnormalized hierarchical clustering using a Pearson's correlation of the phenotypic profiles of 4281 nonessential genes.

Transcriptomic and epigenetic changes associated with Factor 1 in the scMT data Transcriptomic and epigenetic changes associated with Factor 1 in the scMT.

48 clinically relevant GPCR receptors mapped using MYTH

Comparison of proteomics and RNA‐Seq data.

Comparison of nuclear surface area of HeLa and RKO cells

Simulation showing that the cell length variability of the entire population can mask abnormal cell length variability at a specific cell cycle period.

Kinome‐wide activity regulation derived from known substrates and 41 quantitative phosphoproteomic studies Kinome‐wide activity regulation derived from.

An integrated NHR network.

Proliferative advantage depends on environmental dynamics

Stage‐dependent diurnal transcript changes.

Effect of HDAC inhibition on the steady‐state and dynamic transcriptional response and associated noise. Related to Fig 7 Effect of HDAC inhibition on.

Melting behavior of protein complexes

Nedd4 proteins. Nedd4 proteins. (A) Schematic representation of rNedd4‐1, hNedd4‐1 and hNedd4‐2 (not to scale), with % amino‐acid identity between them.

Experimental validation of predicted endocytosis functions in human.

Global and focused views of human interaction map.

Correlation of flux and enzyme concentration (inferred from transcripts) changes for reactions in central metabolism. Correlation of flux and enzyme concentration.

Integration of proteomic data into the model

The transcriptional behavior of GREB1 changes with estrogen dose and exhibits considerable cell‐to‐cell variation (see also Fig EV2 and Movie EV2)‏ The.

Perturbation of ligand depletion affects the ultrasensitivity of long‐term P‐Smad2 responses to different doses of TGF‐β stimulation. Perturbation of ligand.

Many of the diseases associated with high coevolution scores share genetic components. Many of the diseases associated with high coevolution scores share.

PhoB also translocates to plant nuclei in leaf and crown cells in response to HK activation with exogenous cytokinin. PhoB also translocates to plant nuclei.

Kinetics of GREB1 induction by estrogen in single cells (see also Fig EV4 and Movie EV3)‏ Kinetics of GREB1 induction by estrogen in single cells (see.

NMR spectra of Erk. NMR spectra of Erk. (A) Superimposed 1H/15N HSQC spectra of Erk‐pTpY (black) and Erk‐TY (red). Blue circles and arrows mark the C‐terminal.

Fraction of flux entering the PEP‐glyoxylate cycle as a function of hexose uptake rate in batch (A) and chemostat (B) cultures. Fraction of flux entering.

Oscillations in isotopic labeling of TCA cycle metabolites throughout the cell cycle from [U‐13C]‐glucose show induced glycolytic flux into TCA cycle in.

DPP4 release of explants obtained from adipose tissue of lean controls and obese patients before and after bariatric surgery, and linear correlation with.

Changes of major clinical and biochemical characteristics at baseline and during follow-up in different groups. Changes of major clinical and biochemical.

Presentation transcript:

Statistical colorings of 1H NMR estimates of biochemical variables. Statistical colorings of 1H NMR estimates of biochemical variables. (A–I) Quantitative estimates of biochemical variables based on the statistical modeling of the 1H NMR spectra, and visualized on the SOM that was obtained previously from the same data. Regression model estimates for (A) serum triglyceride concentration, (B) cholesterol level, (C) HDL2 cholesterol and (D) serum creatinine. The colors of the map units indicate the averaged estimates for patients who reside in a given region. (E) Concentrations of serum urea were obtained by direct peak integration around 5.68 p.p.m. and (E) albumin concentration was estimated by parametric line fitting in the aliphatic region of the LIPO window. (G) Lactate signal at 4.05 p.p.m. (H) acetate at 1.86 p.p.m. and (I) glucose at 3.44 p.p.m. were quantified by peak integration. Ville‐Petteri Mäkinen et al. Mol Syst Biol 2008;4:167 © as stated in the article, figure or figure legend