by Katie Ayers, Loretta M. Byrne, Anthony DeMatteo, and Nancy J. Brown

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by Katie Ayers, Loretta M. Byrne, Anthony DeMatteo, and Nancy J. Brown Differential Effects of Nebivolol and Metoprolol on Insulin Sensitivity and Plasminogen Activator Inhibitor in the Metabolic Syndrome by Katie Ayers, Loretta M. Byrne, Anthony DeMatteo, and Nancy J. Brown Hypertension Volume 59(4):893-898 March 14, 2012 Copyright © American Heart Association, Inc. All rights reserved.

Study protocol. Study protocol. Top panel shows overall study protocol. Bottom panel shows protocol for frequently sampled intravenous glucose tolerance test performed on each study day. Katie Ayers et al. Hypertension. 2012;59:893-898 Copyright © American Heart Association, Inc. All rights reserved.

Effect of metoprolol and nebivolol on systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). Effect of metoprolol and nebivolol on systolic blood pressure (SBP), diastolic blood pressure (DBP), and heart rate (HR). Pressures are measured in millimeter of mercury (mm Hg) and heart rate in beats per minute (bpm). Changes are shown as both absolute change (Δ) and percentage of change (%Δ) vs baseline. , metoprolol; , nebivolol. Katie Ayers et al. Hypertension. 2012;59:893-898 Copyright © American Heart Association, Inc. All rights reserved.

Effect of metoprolol and nebivolol on plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA). *P<0.05 vs pretreatment, †P=0.05 vs the metoprolol treatment group, after controlling for race and baseline PAI-1 antigen. , metoprolol; , nebivolol. Effect of metoprolol and nebivolol on plasminogen activator inhibitor 1 (PAI-1) and tissue plasminogen activator (t-PA). *P<0.05 vs pretreatment, †P=0.05 vs the metoprolol treatment group, after controlling for race and baseline PAI-1 antigen. , metoprolol; , nebivolol. Katie Ayers et al. Hypertension. 2012;59:893-898 Copyright © American Heart Association, Inc. All rights reserved.