Diet-induced obesity drives negative mouse vein graft wall remodeling

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Presentation transcript:

Diet-induced obesity drives negative mouse vein graft wall remodeling Peng Yu, MD, PhD, Binh T. Nguyen, MD, Ming Tao, MD, Tianyu Jiang, BS, C. Keith Ozaki, MD Journal of Vascular Surgery Volume 59, Issue 6, Pages 1670-1676 (June 2014) DOI: 10.1016/j.jvs.2013.05.033 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 1 Weight curves of vein-grafted mice (C57BL/6J or CD11c-/-) with 60-kcal% high-fat diet (diet-induced obesity [DIO]) or 10-kcal% standard chow (Normal). Values are shown as mean ± standard error of the mean. Journal of Vascular Surgery 2014 59, 1670-1676DOI: (10.1016/j.jvs.2013.05.033) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 2 Serial cross-sectional analysis of vein graft (midgraft portion) wall adaptation in C57BL/6J (A-E) and CD11c-/- (F-J), normal chow vs diet-induced obesity (DIO) mouse midgraft focal stenosis model. A and F, Mean calculated lumen area. B and G, Mean internal elastic lamina (IEL) perimeter. C and H, Mean intima thickness. D and I, Mean media + adventitia thickness. E and J, Mean intima/(media + adventitia) thickness ratio. Values were shown as means ± standard error of the mean. *P < .05 and **P < .01 vs the same location of vein graft in normal chow counterpart mice. K-N, Representative Masson's trichrome stained images at 400 μm distal to midgraft focal stenosis (D400). K, C57 Normal. L, C57 DIO. M, CD11c-/- Normal. N, CD11c-/- DIO. Three hand-drawn black lines in each image delineate the boundaries of different layers of vein graft wall. From the lumen to the outside: lumen boundary, IEL, and outside boundary. Scale bar = 200 μm. Journal of Vascular Surgery 2014 59, 1670-1676DOI: (10.1016/j.jvs.2013.05.033) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 3 Morphologic analysis of vein graft wall adaptation with outflow focal stenosis, in C57BL/6J normal chow vs diet-induced obesity (DIO) mice. A, Mean calculated lumen area. B, Mean internal elastic lamina (IEL) perimeter. C, Mean intima thickness. D, Mean media + adventitia thickness. E, Mean intima/(media + adventitia) thickness ratio. Values were shown as means ± standard error of the mean. Journal of Vascular Surgery 2014 59, 1670-1676DOI: (10.1016/j.jvs.2013.05.033) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 4 The representative CD11c immunohistochemical images and the quantitative analysis of midgraft stenotic vein graft wall in C57BL/6J normal chow vs diet-induced obesity (DIO) mice. Day-7 vein grafts were acetone fixed and cryosectioned; day-28 grafts were formalin fixed and citrate buffer prepared. Note the brown membrane labeling of irregular-shaped cells mainly in the adventitial or adjacent soft tissue of vein graft wall. Scale bars = 50 μm. *P < .05 vs C57 normal chow mice at the same time point. SEM, Standard error of the mean. Journal of Vascular Surgery 2014 59, 1670-1676DOI: (10.1016/j.jvs.2013.05.033) Copyright © 2014 Society for Vascular Surgery Terms and Conditions