Lurie Children’s Strategic Research Initiative: Perinatal Origins of Childhood Disease: Research and Prevention at the Maternal-Fetal Interface A DevSci Healthier Earlier Translational Partnership MOVING THE HEALTHIER, EARLIER DIAL PROMOTING HEALTHY BRAIN DEVELOPMENT First experimental effort to improve adverse neurodevelopmental outcomes by reducing prenatal stress Approach designed for rapid clinical and community-based application Critical evidence base necessary for driving comprehensive pediatric health promotion beginning prenatally Blending advances in prevention science, health technology, developmental science, and neuroscience transforms capacity to alter health trajectories before birth Design Randomized controlled trial (n = 200) pregnant women Prenatal Intervention Customized prenatal stress reduction Mindfulness enhancement Tailored feedback Neurodevelopmental Outcomes (birth – 1 year) Natural sleep MRI Eye tracking Developmental phenotyping BLENDING DIVERSE PERSPECTIVES AROUND A COMMON DEVELOPMENTAL QUESTION Elizabeth Norton, PhD Developmental Cognitive Neuroscientist, CSD/SOC How does early life stress alter the trajectory of the developing brain? Amelie Petitclerc, PhD Developmental/Clinical Psychologist, MSS/FSM What is the earliest developmental timepoint that child disruptive behavior can be prevented? Laurie Wakschlag, PhD (PI) Developmental Psychologist, MSS/FSM Does early life stress cause adverse neurodevelopmental outcomes? Darius Tandon, PhD Community Psychologist, MSS/FSM & CCH/NUCATS What is the impact of a tailored, mindfulness-enhanced prenatal stress reduction intervention on maternal wellbeing? Judy Moskowitz, PhD, MPH Social Psychologist, MSS/FSM & Osher Center for Integrative Medicine Can subjective stress / emotion ratings determine optimal delivery timing of tailored stress-reduction feedback? UNIFYING OBJECTIVE: DISCOVER WHETHER IMPROVING GESTATIONAL BIOLOGY IMPROVES EARLY NEURODEVELOPMENTAL HEALTH William Grobman, MD, MBA Maternal:Fetal Medicine, OB-Gyn/FSM Are obstetric outcomes following a tailored prenatal stress reduction intervention affected by race, ethnicity, and socioeconomic status? Brad Marino, MD, MPP, MSCE, FAHA Pediatrician, PEDS/FSM/Lurie Children’s Can prenatal prevention improve quality of life for high risk infants? Michael Bass, MS Health Information Technologist, MSS/FSM What are the human computer interaction factors related to developing viable technology-assisted prenatal interventions? John Rogers, PhD Bioengineer & Materials Scientist, McCormick Can unobtrusive smart physiological stress monitoring devices detect stress levels in pregnant women? Nabil Alshurafa, PhD Computer Scientist, Prev Med/FSM & EECS/McCormick What is the optimal predictive algorithm to detect real-time maternal stress response?