Cell Competition: Dying for Communal Interest

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Presentation transcript:

Cell Competition: Dying for Communal Interest Maximilien Courgeon, Nikolaos Konstantinides, Claude Desplan  Current Biology  Volume 25, Issue 8, Pages R339-R341 (April 2015) DOI: 10.1016/j.cub.2015.02.047 Copyright © 2015 Elsevier Ltd Terms and Conditions

Figure 1 Cell competition in the Drosophila wing disc. (A) In a wild-type background (WT), clones of heterozygous Minute cells (M/+, in green) are cleared from the wing disc 72 h after competition started (top). In a fwe or an azot mutant background, M/+ cells are no longer eliminated and are still present 72 h after clone induction (bottom). (B) WT cells express the fweUbi isoform whereas M/+ cells express both fweLose isoforms. Following flower-mediated fitness comparison, M/+ cells start to express azot and are eliminated from the tissue through Hid-dependent apoptosis. Current Biology 2015 25, R339-R341DOI: (10.1016/j.cub.2015.02.047) Copyright © 2015 Elsevier Ltd Terms and Conditions