Genomewide Linkage Analysis Identifies Polymorphism in the Human Interferon-γ Receptor Affecting Helicobacter pylori Infection Thorsten Thye, Gerd D.

Slides:

Advertisements

Similar presentations

Replication Stress Induces Genome-wide Copy Number Changes in Human Cells that Resemble Polymorphic and Pathogenic Variants Martin F. Arlt, Jennifer G.

Advertisements

Functional Analysis of the Neurofibromatosis Type 2 Protein by Means of Disease- Causing Point Mutations Renee P. Stokowski, David R. Cox The American.

Gene Preference in Maple Syrup Urine Disease Mary M. Nellis, Dean J. Danner The American Journal of Human Genetics Volume 68, Issue 1, Pages (January.

Genomewide Comparison of DNA Sequences between Humans and Chimpanzees Ingo Ebersberger, Dirk Metzler, Carsten Schwarz, Svante Pääbo The American Journal.

Quantitative-Trait-Locus Analysis of Body-Mass Index and of Stature, by Combined Analysis of Genome Scans of Five Finnish Study Groups Markus Perola,

Human Pedigree-Based Quantitative-Trait–Locus Mapping: Localization of Two Genes Influencing HDL-Cholesterol Metabolism Laura Almasy, James E. Hixson,

A Novel Linkage to Generalized Vitiligo on 4q13-q21 Identified in a Genomewide Linkage Analysis of Chinese Families Jian-Jun Chen, Wei Huang, Jin-Ping.

L. Boyanova Clinical Microbiology and Infection

Harald H.H. Göring, Joseph D. Terwilliger

Homozygosity Mapping in Families with Joubert Syndrome Identifies a Locus on Chromosome 9q34.3 and Evidence for Genetic Heterogeneity Kathrin Saar, Lihadh.

Rapid Simulation of P Values for Product Methods and Multiple-Testing Adjustment in Association Studies S.R. Seaman, B. Müller-Myhsok The American Journal.

A Second Locus for Familial Generalized Epilepsy with Febrile Seizures Plus Maps to Chromosome 2q21-q33 Stéphanie Baulac, Isabelle Gourfinkel-An, Fabienne.

Robustness and Power of the Maximum-Likelihood–Binomial and Maximum-Likelihood– Score Methods, in Multipoint Linkage Analysis of Affected-Sibship Data

Use of Homozygosity Mapping to Identify a Region on Chromosome 1 Bearing a Defective Gene That Causes Autosomal Recessive Homozygous Hypercholesterolemia.

Comparison of Microsatellites Versus Single-Nucleotide Polymorphisms in a Genome Linkage Screen for Prostate Cancer–Susceptibility Loci Daniel J. Schaid,

D. E. Grice, K. A. Halmi, M. M. Fichter, M. Strober, D. B. Woodside, J

Genomewide Scan in German Families Reveals Evidence for a Novel Psoriasis- Susceptibility Locus on Chromosome 19p13 Young-Ae Lee, Franz Rüschendorf, Christine.

Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4 Katrina A.B. Goddard, John S. Witte, Brian K.

Frances Busfield, David L. Duffy, Janine B. Kesting, Shelley M

A Major Susceptibility Locus Influencing Plasma Triglyceride Concentrations Is Located on Chromosome 15q in Mexican Americans Ravindranath Duggirala,

Genomewide Linkage Scan for Myopia Susceptibility Loci among Ashkenazi Jewish Families Shows Evidence of Linkage on Chromosome 22q12 Dwight Stambolian,

Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs Jian Huang, Yanming Jiang The.

Linkage Disequilibrium Mapping of Schizophrenia Susceptibility to the CAPON Region of Chromosome 1q22 Linda M. Brzustowicz, Jaime Simone, Paria Mohseni,

A Whole-Genome Scan in 164 Dutch Sib Pairs with Attention-Deficit/Hyperactivity Disorder: Suggestive Evidence for Linkage on Chromosomes 7p and 15q S.C.

Anxiety with Panic Disorder Linked to Chromosome 9q in Iceland

Linkage Thresholds for Two-stage Genome Scans

A Combined Linkage-Physical Map of the Human Genome

The Gene for Severe Combined Immunodeficiency Disease in Athabascan-Speaking Native Americans Is Located on Chromosome 10p Lanying Li, Dennis Drayna,

The American Journal of Human Genetics

Elizabeth Theusch, Analabha Basu, Jane Gitschier

A Quantitative-Trait Locus in the Human Factor XII Gene Influences Both Plasma Factor XII Levels and Susceptibility to Thrombotic Disease José Manuel.

Evidence for a Nonallelic Heterogeneity of Epidermodysplasia Verruciformis with Two Susceptibility Loci Mapped to Chromosome Regions 2p21–p24 and 17q25

Danielle Posthuma, Michelle Luciano, Eco J. C. de Geus, Margie J

A Second Gene for Autosomal Dominant Möbius Syndrome Is Localized to Chromosome 10q, in a Dutch Family H.T.F.M. Verzijl, B. van den Helm, B. Veldman,

Chuanhui Dong, Wei-Dong Li, Frank Geller, Lei Lei, Ding Li, Olga Y

Familial Juvenile Hyperuricemic Nephropathy: Localization of the Gene on Chromosome 16p11.2—and Evidence for Genetic Heterogeneity Blanka Stibůrková,

Figure 2 Linkage analysis of chromosome 19

Hal M. Hoffman, Fred A. Wright, David H. Broide, Alan A

Stephen C. Pratt, Mark J. Daly, Leonid Kruglyak

Model-Free Linkage Analysis with Covariates Confirms Linkage of Prostate Cancer to Chromosomes 1 and 4 Katrina A.B. Goddard, John S. Witte, Brian K.

A Syndrome of Severe Mental Retardation, Spasticity, and Tapetoretinal Degeneration Linked to Chromosome 15q24 S.J. Mitchell, D.P. McHale, D.A. Campbell,

Attention Deficit Hyperactivity Disorder: Fine Mapping Supports Linkage to 5p13, 6q12, 16p13, and 17p11 Matthew N. Ogdie, Simon E. Fisher, May Yang,

The SNP Endgame: A Multidisciplinary Approach*

Erratum The American Journal of Human Genetics

A Genomewide Linkage Scan for Quantitative-Trait Loci for Obesity Phenotypes Hong-Wen Deng, Hongyi Deng, Yong-Jun Liu, Yao-Zhong Liu, Fu-Hua Xu, Hui Shen,

Michael P. Epstein, Xihong Lin, Michael Boehnke

On a Randomization Procedure in Linkage Analysis

D. E. Grice, K. A. Halmi, M. M. Fichter, M. Strober, D. B. Woodside, J

Genomewide Linkage Analysis of Quantitative Spirometric Phenotypes in Severe Early- Onset Chronic Obstructive Pulmonary Disease Edwin K. Silverman, Lyle.

Genomewide Scan in Families with Schizophrenia from the Founder Population of Afrikaners Reveals Evidence for Linkage and Uniparental Disomy on Chromosome.

Volume 69, Issue 3, Pages (February 2006)

Nonpaternity in Linkage Studies of Extremely Discordant Sib Pairs

Suzanne M. Leal, Jurg Ott The American Journal of Human Genetics

A Gene Locus Responsible for the Familial Hair Shaft Abnormality Pili Annulati Maps to Chromosome 12q24.32–24.33 Kathrin A. Giehl, Gertrud N. Eckstein,

The PARK8 Locus in Autosomal Dominant Parkinsonism: Confirmation of Linkage and Further Delineation of the Disease-Containing Interval Alexander Zimprich,

Bruno Bucheton, Laurent Abel, Sayda El-Safi, Musa M

Genomewide Search and Genetic Localization of a Second Gene Associated with Autosomal Dominant Branchio-Oto-Renal Syndrome: Clinical and Genetic Implications

A New Locus for Autosomal Recessive Hypercholesterolemia Maps to Human Chromosome 15q25-q26 Milco Ciccarese, Adolfo Pacifico, Giancarlo Tonolo, Paolo.

Genome Scan of Human Systemic Lupus Erythematosus by Regression Modeling: Evidence of Linkage and Epistasis at 4p C. Gray-McGuire, K.L. Moser,

Genome Screen to Identify Susceptibility Genes for Parkinson Disease in a Sample without parkin Mutations Nathan Pankratz, William C. Nichols, Sean K.

Linkage Analyses at the Chromosome 1 Loci 1q24-25 (HPC1), 1q42

Volume 4, Issue 1, Pages 2-3 (February 2006)

A Quantitative-Trait Locus on Chromosome 6p Influences Different Aspects of Developmental Dyslexia Simon E. Fisher, Angela J. Marlow, Janine Lamb, Elena.

Alice S. Whittemore, Jerry Halpern

Kathleen A. Daly, W. Mark Brown, Fernando Segade, Donald W

Homozygosity Mapping in Families with Joubert Syndrome Identifies a Locus on Chromosome 9q34.3 and Evidence for Genetic Heterogeneity Kathrin Saar, Lihadh.

Genetic Linkage Analysis of a Dichotomous Trait Incorporating a Tightly Linked Quantitative Trait in Affected Sib Pairs Jian Huang, Yanming Jiang The.

A Novel Linkage to Generalized Vitiligo on 4q13-q21 Identified in a Genomewide Linkage Analysis of Chinese Families Jian-Jun Chen, Wei Huang, Jin-Ping.

Kung-Yee Liang, Fang-Chi Hsu, Terri H. Beaty, Kathleen C. Barnes

Genomewide Comparison of DNA Sequences between Humans and Chimpanzees

Presentation transcript:

Genomewide Linkage Analysis Identifies Polymorphism in the Human Interferon-γ Receptor Affecting Helicobacter pylori Infection Thorsten Thye, Gerd D. Burchard, Manfred Nilius, Bertram Müller-Myhsok, Rolf D. Horstmann The American Journal of Human Genetics Volume 72, Issue 2, Pages 448-453 (February 2003) DOI: 10.1086/367714 Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 1 Genomewide linkage analysis of 143 sib pairs for the intensity of H. pylori infection, as defined by serum concentrations of H. pylori–reactive IgG. The American Journal of Human Genetics 2003 72, 448-453DOI: (10.1086/367714) Copyright © 2003 The American Society of Human Genetics Terms and Conditions

Figure 2 Multipoint LOD scores on chromosome 6q. a, Detailed profile of the multipoint LOD scores on chromosome 6q. b,Change in multipoint LOD scores when STR marker FA1, which is located in intron 6 of IFNGR1 (Altare et al. 1998), is included. c, Change in multipoint LOD scores when IFNGR1 variants –56T→C, H318P, and L450P are included as additional markers. The increase in LOD score can be explained by the combined markers becoming successively more informative, as indicated by an increment in information content from 0.73 to 0.84 and 0.94 (Kruglyak and Lander 1995). The American Journal of Human Genetics 2003 72, 448-453DOI: (10.1086/367714) Copyright © 2003 The American Society of Human Genetics Terms and Conditions