Perioperative Blood Transfusion Is Associated With Worse Clinical Outcomes in Resected Lung Cancer Ting Wang, MD, Lili Luo, MD, He Huang, MD, Jingrui.

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Perioperative Blood Transfusion Is Associated With Worse Clinical Outcomes in Resected Lung Cancer Ting Wang, MD, Lili Luo, MD, He Huang, MD, Jingrui Yu, MD, Changchuan Pan, MD, Xiaohong Cai, MD, Bin Hu, MD, Xude Yin, MD The Annals of Thoracic Surgery Volume 97, Issue 5, Pages 1827-1837 (May 2014) DOI: 10.1016/j.athoracsur.2013.12.044 Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Flowchart shows the search result of the meta-analysis. (CNKI = China National Knowledge Infrastructure.) The Annals of Thoracic Surgery 2014 97, 1827-1837DOI: (10.1016/j.athoracsur.2013.12.044) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Forest plots show the effect of allogenic blood transfusion on the (A) hazard ratio for overall survival, (B) the hazard ratio for progression-free survival, (C) the relative risk for recurrence rate, and (D) the odds ratio for 5-year survival in patients with surgically resected lung cancer. The solid squares denote the mean difference and are proportional to weights used in meta-analysis. The solid vertical line indicates no effect. The dashed line indicates the summary measure, with the associated diamond denoting the weighted mean difference and the lateral tips of the diamond indicating the associated confidence intervals (CIs). The horizontal lines represents the 95% CIs. (ID = identifier.) The Annals of Thoracic Surgery 2014 97, 1827-1837DOI: (10.1016/j.athoracsur.2013.12.044) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Subgroup analyses by stage I patients of the effect of allogenic blood transfusion on (A) the hazard ratio for overall survival, (B) the hazard ratio for progression-free survival, (C) the relative risk for recurrence rate, and (D) the odds ratio for 5-year survival. The solid squares denote the mean difference and are proportional to weights used in meta-analysis. The solid vertical line indicates no effect. The dashed line indicates the summary measure, with the associated diamond denoting the weighted mean difference and the lateral tips of the diamond indicating the associated confidence intervals (CIs). The horizontal lines represents the 95% CIs. (ID = identifier.) The Annals of Thoracic Surgery 2014 97, 1827-1837DOI: (10.1016/j.athoracsur.2013.12.044) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Funnel plots are presented for (A) overall survival, (B) progression-free survival, (C) recurrence rate, and (D) 5-year survival in patients with surgically resected lung cancer. (HR = hazard ratio; RR = relative risk.) The Annals of Thoracic Surgery 2014 97, 1827-1837DOI: (10.1016/j.athoracsur.2013.12.044) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 The influence of analysis of individual studies is shown on the pooled estimate of (A) overall survival, (B) progression-free survival, (C) recurrence rate, and (D) 5-year survival. The left and right vertical lines indicate the lower and upper limits of the confidence interval (CI), respectively, the circles denote the estimate, and the dashed lines indicate the CI. The Annals of Thoracic Surgery 2014 97, 1827-1837DOI: (10.1016/j.athoracsur.2013.12.044) Copyright © 2014 The Society of Thoracic Surgeons Terms and Conditions