A randomized trial evaluating the efficacy and safety of alirocumab in South Korea and Taiwan (ODYSSEY KT) Kwang Kon Koh, MD, PhD, FACC, Chang Wook Nam,

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A randomized trial evaluating the efficacy and safety of alirocumab in South Korea and Taiwan (ODYSSEY KT) Kwang Kon Koh, MD, PhD, FACC, Chang Wook Nam, MD, PhD, FACC, Ting-Hsing Chao, MD, FACC, FESC, Ming-En Liu, MD, Chiung- Jen Wu, MD, Dong-Soo Kim, MD, PhD, Chong-Jin Kim, MD, PhD, Ivy Li, MSc, Jianyong Li, MD, Marie T. Baccara-Dinet, MD, MSc, Pi- Jung Hsiao, MD, MS, Chern-En Chiang, MD, PhD, FACC Journal of Clinical Lipidology Volume 12, Issue 1, Pages 162-172.e6 (January 2018) DOI: 10.1016/j.jacl.2017.09.007 Copyright © 2017 National Lipid Association Terms and Conditions

Figure 1 ODYSSEY KT study design. FU, follow-up; LDL-C, low-density lipoprotein cholesterol; LLT, lipid-lowering therapy; NCEP ATP III, National Cholesterol Education Program Adult Treatment Panel III; Q2W, every 2 weeks; R, randomization; SC, subcutaneously; TLC, therapeutic lifestyle changes; W, week. Journal of Clinical Lipidology 2018 12, 162-172.e6DOI: (10.1016/j.jacl.2017.09.007) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 2 Patient flow through the ODYSSEY KT study. AE, adverse event; mITT, modified intent-to-treat; ITT, intent-to-treat. Journal of Clinical Lipidology 2018 12, 162-172.e6DOI: (10.1016/j.jacl.2017.09.007) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 3 Calculated LDL-C levels over time (ITT analysis). ITT, intent-to-treat; LDL-C, low-density lipoprotein cholesterol; LS, least squares; SE, standard error. Journal of Clinical Lipidology 2018 12, 162-172.e6DOI: (10.1016/j.jacl.2017.09.007) Copyright © 2017 National Lipid Association Terms and Conditions