MRI of a Novel Murine Working Heart Transplant Model

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Presentation transcript:

MRI of a Novel Murine Working Heart Transplant Model by Jose-Luiz Figueiredo, Matthias Nahrendorf, David E. Sosnovik, and Ralph Weissleder Circ Heart Fail Volume 2(3):272-274 May 1, 2009 Copyright © American Heart Association, Inc. All rights reserved.

Figure. A, the surgical approach and direction of blood flow (arrows) are shown. Figure. A, the surgical approach and direction of blood flow (arrows) are shown. B, The explanted donor heart/lung package is stored in ice-cold cardioplegic solution before implantation into the recipient. C, Surgical field after transplantation (magnification ×2). D, Vascular anastomoses (magnification ×4). E, Typical ECG trace recorded during imaging. The gradient noise is visible during every other heart cycle. The ECG of the heterotopic graft can be isolated from the orthotopic recipient heart by attaching leads to the hind legs of the mouse. F and G, Diastolic and systolic mid-ventricular cine MRI frames. MRI was performed on day 1 after isografting using isoflurane anesthesia (1.5%, O2 2 L/min) on a 7-T scanner (Bruker Pharmascan, Billerica, Mass). Cine images were obtained with ECG and respiratory gating (SA Instruments, Stony Brook, NY) using a gradient echo cine sequence and a dedicated mouse cardiac birdcage coil (Rapid Biomedical, Wuerzburg, Germany) with the following imaging parameters: echo time, 2.7 ms; 16 frames per RR interval (repetition time, 10 ms); in-plane resolution, 200×200 μm; slice thickness, 1 mm; number of excitations (NEX), 4. H and I, Diastolic and systolic mid-ventricular frames from a tagged cine MRI acquisition. Tagging was achieved with a spatial modulation of magnetization (SPAMM)5 prepulse of 17.8-ms duration immediately after the QRS trigger, with 1 mm distance between taglines and 0.2 mm line thickness. All other acquisition parameters were identical to those described earlier for the nontagged gradient echo cine. PA indicates pulmonary artery; PV, pulmonary vein; LV, left ventricle; RV, right ventricle. Jose-Luiz Figueiredo et al. Circ Heart Fail. 2009;2:272-274 Copyright © American Heart Association, Inc. All rights reserved.