Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy Akihiko.

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Presentation transcript:

Association of CD4+ T-lymphocyte counts and new thymic emigrants in HIV-infected children during successful highly active antiretroviral therapy Akihiko Saitoh, MD, Kumud K. Singh, PhD, Sharsti Sandall, BS, Christine A. Powell, MA, Terrence Fenton, EdD, Courtney V. Fletcher, PharmD, Karen Hsia, PhD, Stephen A. Spector, MD Journal of Allergy and Clinical Immunology Volume 117, Issue 4, Pages 909-915 (April 2006) DOI: 10.1016/j.jaci.2006.01.013 Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Positive correlation between TREC levels and naive CD4+ T-lymphocyte counts. There was a strong positive correlation between TREC levels and naive CD4+ T-lymphocyte counts (CD4+CD45RA+; r = .92; P < .001) at week 20. Journal of Allergy and Clinical Immunology 2006 117, 909-915DOI: (10.1016/j.jaci.2006.01.013) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Comparison of median HIV-1 intracellular DNA levels between rapid responders (HIV-1 RNA < 50 copies/mL by week 8; white bars) and slow responders (HIV-1 RNA < 50 copies/mL after week 8; gray bars). Slow responders had persistently higher median HIV-1 intracellular DNA levels compared with rapid responders during HAART (P < .001). Data shown are expressed as the median value ± 25th and 75th percentiles. ∗P < .05; ∗∗P < .01. Journal of Allergy and Clinical Immunology 2006 117, 909-915DOI: (10.1016/j.jaci.2006.01.013) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 3 Comparison of CD4+ T-lymphocyte counts between rapid responders (HIV-1 RNA < 50 copies/mL by week 8; white bars) and slow responders (HIV-1 RNA < 50 copies/mL after week 8; gray bars). Slow responders had equal or higher median CD4+ T-lymphocyte counts throughout HAART compared with rapid responders (P = .12) that reached significance at week 80 (P = .05) and week 104 (P = .04). Data shown are expressed as the median value ± 25th and 75th percentiles. ∗P < .05. Journal of Allergy and Clinical Immunology 2006 117, 909-915DOI: (10.1016/j.jaci.2006.01.013) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 4 Comparison of TREC levels between rapid responders (HIV-1 RNA < 50 copies/mL by week 8; white bars) and slow responders (HIV-1 RNA levels < 50 copies/mL after week 8; gray bars). TREC levels were higher in slow responders than in rapid responders during HAART (P < .001) and reached significance at week 48 (P = .004) and week 80 (P = .01). Data shown are expressed as the median value ± 25th and 75th percentiles. ∗P < .05. Journal of Allergy and Clinical Immunology 2006 117, 909-915DOI: (10.1016/j.jaci.2006.01.013) Copyright © 2006 American Academy of Allergy, Asthma and Immunology Terms and Conditions