By: Brent Hefty Greg Tevis project advisor:

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Design and Development of a Discrete Simulation for Optic Nerve Development By: Brent Hefty Greg Tevis project advisor: Samuel F. Hunter, M.D., Ph.D.

Overall Purpose To design and implement a simulation for central nervous system generation and repair as a function of micro-environmental interactions.

Data Structure Development Main Tables Axon Table Oligodendrocyte Table Myelin Table Astrocyte Table Astrocyte Process Table

Sample Table

Area Of Interest

Axon Representation

Oligodendrocyte Representation

Myelination Process Representation Myelination Process Components Myelinating Oligodendrocyte Process attached to axon Maximum of 10 - 20 turns at .07 um per turn.

Diagram of Total Myelination

Astrocyte Representation

Proposed Values for Simulation Axon diameter small = 0.5um large = 1.0 um Oligodendrocyte 6 - 10 um (l, w, h) Myelin Sheath .007 / turn 10 - 20 turns = .1-.2um Astrocyte 20 - 40 um (l, w, h) Astrocyte Process max = 60 um

Total Proposed Numbers for Simulation Total Axons large = 742 small = 495 total = 1237 axons in 5um segments over 2mm. Oligodendrocytes Astrocytes

Project Status Complete Future Endeavors Initial tables with fields decided upon. Decision on the units and type of number representation for fields. Web page design kept current. Future Endeavors Rules for growth in data structure to be established. Actual data insertion into tables. Research on VB and SQL. Design and implementation of growth algorithms. (wish)