Incidence rates for the three common osteoporotic fractures 9/21/2018 OSTEOPOROSIS Postgraduate Centre Series

Osteovision 9/21/2018 OSTEOPOROSIS

% of US Caucasian women in WHO categories Bone density losses with aging Osteovision % of US Caucasian women in WHO categories 9/21/2018 OSTEOPOROSIS

Bone density at different age groups . Age 25  Age 50  Age 65  Age 80  Normal  84% 66% 40% 10% Osteopenia  14% 32% 36% Osteoporosis  1% 13% 27% Established osteoporosis  7% Osteovision 9/21/2018 OSTEOPOROSIS

Magnitude of the Problem How many suffer from osteoporosis? GEC/PA 9/21/2018 OSTEOPOROSIS

Prevalence in the United States 40% n 10 million women have osteoporosis 1 18 million women are at risk of developing the disease -50% of women aged 50 years or older will suffer an osteoporosis-related fracture within their lifetime 2,3 1 National Osteoporosis Foundation. Osteoporos Int . 1998;8:SJ -588. 2 Chrischilles EA, et al. Arch Intern Med. 1991;151:2026 - 2032. 3 Melton LJ, et al. J Bone Miner Res. 1992;7(9):1005-1010. GEC/PA 9/21/2018 OSTEOPOROSIS

States with the Greatest Number of Men and Women with Osteoporosis California Florida New York Texas Pennsylvania 1997 NOF State-by-State report GEC/PA 9/21/2018 OSTEOPOROSIS

Pennsylvanians over age 50c Osteoporosis affects over half a million Pennsylvanians over age 50c 1997 NOF State-by-State report GEC/PA 9/21/2018 OSTEOPOROSIS

Hip Fracture Risk of a Woman Suffering a During Her Lifetime 1 out of 6 Women will have a Hip Fracture 9/21/2018 OSTEOPOROSIS

The Risk of a Woman Suffering a Hip Fracture During Her Lifetime … … is equal to the Combined Risk of getting Breast, Uterine & Ovarian Cancer 9/21/2018 OSTEOPOROSIS

1.5 Million Fractures Per Year Incidence of fracture in the U.S. 1.5 Million Fractures Per Year Most Common: Spine Hip Wrist (Colles’) 9/21/2018 OSTEOPOROSIS

Complete Recovery One Year After Hip Fracture 48.5% 51.5% 60.0% 40.0% Recovered Not Recovered Walking Physical ADL’s Magaziner et al. J Geront 1990; 45: M101-7