Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20.

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Probiotic supplement reduces risk of necrotizing enterocolitis and mortality in preterm very low-birth-weight infants: an updated meta-analysis of 20 randomized, controlled trials Quanzhen Wang, Jing Dong, Yimin Zhu Journal of Pediatric Surgery Volume 47, Issue 1, Pages 241-248 (January 2012) DOI: 10.1016/j.jpedsurg.2011.09.064 Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 1 Flowchart of selection of studies for inclusion in the meta-analysis. Journal of Pediatric Surgery 2012 47, 241-248DOI: (10.1016/j.jpedsurg.2011.09.064) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 2 Forest plots of probiotics in preterm infants (A, Effect of probiotics on NEC; B, Effect of probiotics on mortality; C, Effect of probiotics on sepsis). Journal of Pediatric Surgery 2012 47, 241-248DOI: (10.1016/j.jpedsurg.2011.09.064) Copyright © 2012 Elsevier Inc. Terms and Conditions

Fig. 3 Funnel plot to assess publication bias (analysis of effect of probiotic supplement on NEC risk including 20 studies; TEgger test = −1.12; 95% CI, −1.82 to 0.56; PEgger test = .278 > .05). Journal of Pediatric Surgery 2012 47, 241-248DOI: (10.1016/j.jpedsurg.2011.09.064) Copyright © 2012 Elsevier Inc. Terms and Conditions