Comparative Effectiveness of 12 Treatment Strategies for Preventing Contrast-Induced Acute Kidney Injury: A Systematic Review and Bayesian Network Meta-analysis  Xiaole Su, MD, Xinfang Xie, MD, Lijun Liu, MD, Jicheng Lv, MD, Fujian Song, PhD, Vlado Perkovic, MD, Hong Zhang, MD  American Journal of Kidney Diseases  Volume 69, Issue 1, Pages 69-77 (January 2017) DOI: 10.1053/j.ajkd.2016.07.033 Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 1 Summary of trial identification and selection. Abbreviation: CI-AKI, contrast-induced acute kidney injury. American Journal of Kidney Diseases 2017 69, 69-77DOI: (10.1053/j.ajkd.2016.07.033) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 2 Network of treatment comparisons for Bayesian network meta-analysis. The size of the nodes is proportional to the number of patients randomly assigned to receive the treatment. Directly comparable treatments are linked with a line, the width of which is proportional to the number of trials comparing the connected treatments. Abbreviation: NAC, N-acetylcysteine. American Journal of Kidney Diseases 2017 69, 69-77DOI: (10.1053/j.ajkd.2016.07.033) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 3 Summary of results from NMA (on the lower triangle) and traditional pairwise meta-analysis (on the upper triangle). On the lower triangle, the column-defining treatment is compared to the row-defining treatment, and odds ratios (ORs)<1 favor the column-defining treatment. On the upper triangle, the row-defining treatment is compared to the column-defining treatment, and ORs<1 favor the row-defining treatment. To obtain ORs for comparisons in the opposite direction, reciprocals should be taken. Significant results are in bold. Direct comparisons within 2 inconsistent loops are underlined. Abbreviations: BIC, bicarbonate sodium; BIC+NAC, bicarbonate sodium plus N-acetylcysteine; FEN, fenoldopam; HST, high-dose statin; HST+NAC, high-dose statin plus N-acetylcysteine; HYD, hydration; LST, low-dose statin; NAC, N-acetylcysteine; NAP, natriuretic peptide; NMA, network meta-analysis; PRO, prostaglandin; THE, theophylline; VIT, vitamins and analogues. American Journal of Kidney Diseases 2017 69, 69-77DOI: (10.1053/j.ajkd.2016.07.033) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions

Figure 4 Forest plot for efficacy of 11 active drugs compared to hydration. Treatments are ranked according to their odds ratio (OR) values (vs hydration). Abbreviations: CI-AKI, contrast-induced acute kidney injury; CrI, credible interval; NAC, N-acetylcysteine; SUCRA, surface under the cumulative ranking curve (measure). American Journal of Kidney Diseases 2017 69, 69-77DOI: (10.1053/j.ajkd.2016.07.033) Copyright © 2016 National Kidney Foundation, Inc. Terms and Conditions