Dominant Traits Recessive Traits Freckles No freckles Widow’s peak

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Dominant Traits Recessive Traits Freckles No freckles Widow’s peak Figure 9.8A Dominant Traits Recessive Traits Freckles No freckles Figure 9.8A Examples of single-gene inherited traits in humans Widow’s peak Straight hairline Free earlobe Attached earlobe 1

Table 9.9 Table 9.9 Some Autosomal Disorders in Humans 2

Variations of Mendelian Genetics 5.5 and 5.6

Dihybrid Cross Looks at two pairs of contrasting traits at the same time

Dihybrid Cross Example Round or wrinkled and green or yellow Law of segregation still applies 4 different alleles, 9 possible genotypes, 4 possible phenotypes

Independent Assortment The inheritance of an allele for one characteristic does not affect the inheritance of an allele for a different characteristic. Related to independent orientation during meiosis- homologous chromosomes randomly line up on the left and right side. Independent assortment still applies even if the alleles for the different characteristics are on the same chromosome because of crossing over which occurs during prophase I of meiosis

Law of Segregation vs. Law of Independent Assortment Law of segregation is talking about how haploid gametes are produced through the process of meiosis Law of independent assortment is talking about how the inheritance of one characteristic does not effect the inheritance of other characteristics

Complete Dominance Pea Plant Genotype Phenotype Homozygous dominant (PP) Purple Heterozygous (Pp) Homozygous recessive (pp) White 2 different alleles, 3 possible genotypes, 2 possible phenotypes

Incomplete Dominance Neither allele is purely dominant or recessive The phenotype of the heterozygote is a result of both alleles being expressed Results in an intermediate phenotype

Incomplete Dominance Example Many common garden flowers like the snapdragon have genes for flower color that display incomplete dominance.

Incomplete Dominance Snapdragon Genotype Phenotype Homozygous for red (RR) Red Heterozygous (RW) Pink Homozygous for white (WW) White 2 different alleles, 3 possible genotypes, 3 possible phenotypes

Incomplete Dominance Hypercholesterolemia One example of incomplete dominance in humans is hypercholesterolemia, in which dangerously high levels of cholesterol occur in the blood and heterozygotes have intermediately high cholesterol levels.

Genotypes Hh Heterozygous Figure 9.11B Genotypes Hh Heterozygous HH Homozygous for ability to make LDL receptors hh Homozygous for inability to make LDL receptors Phenotypes LDL LDL receptor Figure 9.11B Incomplete dominance in human hypercholesterolemia Cell Normal Mild disease Severe disease 20

Co-dominance Neither allele is purely dominant or recessive The phenotype of the heterozygote is a result of both alleles being expressed Does not result in a blend or intermediate characteristics Both alleles are expressed separately and equally

Co-dominance Example Many mammals have genes for hair color that display co-dominance

Co-dominance Horse Hair Genotype Phenotype Homozygous for red (RR) Red Heterozygous (RW) Roan Homozygous for white (WW) White 2 different alleles, 3 possible genotypes, 3 possible phenotypes

Multiple Alleles In each example we’ve looked at so far, the trait is a result of the interaction of 2 different alleles. With many traits, however, there are more than 2 possible alleles that you could inherit.

Multiple Alleles Example There are 3 possible alleles for blood type and they display a combination of complete dominance and co-dominance. Allele for blood type A and B are both dominant over the allele for blood type O Allele for blood type A and B are co-dominant

Multiple Alleles ABO Blood Type There are three possible alleles: IA, IB, and i. The combination of two of those alleles determines an individuals blood type. Blood Types (Phenotypes) Possible Genotypes Type A IAIA or IAi Type B IBIB or IBi Type AB IAIB Type O ii

Multiple Alleles ABO Blood Type 3 different alleles, 6 possible genotypes, 4 possible phenotypes

Polygenic Inheritance (Multiple Genes) Multiple genes at different loci and/or on different chromosomes effect a single characteristic Most human traits have some degree of polygenic inheritance Skin color, hair color, eye color, height, body build, intelligence…

Polygenic Inheritance (Multiple Genes) Example There is at least 3 genes that control skin color Combinations result in a blend from very light to very dark Behavior and the environment play an important role as well

Polygenic Inheritance (Multiple Genes) Skin Color 6 different alleles, 27 possible genotypes, 7 possible phenotypes

Sex Determination Humans have 46 chromosomes (23 pairs) 22 pairs of autosomes and one pair of sex chromosomes Sex chromosomes determine the sex and we represent them with an X and a Y. Female = XX Males = XY It is the man’s gene that determines the sex of the child

Sex-Linked Traits X chromosome is much larger than the Y chromosome Genes on the X chromosome are important for both males and females Genes on the Y chromosome are what make a male a male In females characteristics are determined by the interaction of the alleles on each X chromosome In males, since they only have one X chromosome and the Y chromosome is much smaller, some characteristics are determined by a single allele on the X chromosome.

Sex-Linked Traits Example Red-green colorblindness Reduced amount of a chemical in the retina of their eyes Red-green colorblindness is a recessive characteristic that is found on the X chromosome

Sex-Linked Trait Red-Green Colorblindness Male Genotype Phenotype XNY Normal XnY Colorblind

Sex-Linked Trait Red-Green Colorblindness Female Genotype Phenotype XN XN Normal XN Xn Xn Xn Colorblind Carrier- a carrier for an X-linked trait is a female individual who does not exhibit the characteristic but does carry the gene for the trait

Sex-Linked Trait Colorblind father x Heterozygous mother Father with normal vision x Heterozygous mother Colorblind father x Homozygous mother with normal vision Father with normal vision x Colorblind mother

Pedigree Chart that geneticists use to trace the presence or absence of a trait in a number of generations Square = male Circle = female Shaded = has trait Not shaded = does not have trait

Hemophilia X-linked recessive trait “Bleeder’s disease” Hemophilia- genetic disorder that causes individuals to lack an enzyme in the blood that is essential for normal blood clotting Normally minor cuts, bruises, and scrapes can become very serious In the past, individuals with this disorder typically died very young Modern medication can replace the enzyme

Pedigree