Age-Related Differences in Phosphodiesterase Activity and Effects of Chronic Phosphodiesterase Inhibition in Idiopathic Dilated CardiomyopathyCLINICAL.

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Age-Related Differences in Phosphodiesterase Activity and Effects of Chronic Phosphodiesterase Inhibition in Idiopathic Dilated CardiomyopathyCLINICAL PERSPECTIVE by Stephanie J. Nakano, Shelley D. Miyamoto, Matthew Movsesian, Penny Nelson, Brian L. Stauffer, and Carmen C. Sucharov Circ Heart Fail Volume 8(1):57-63 January 20, 2015 Copyright © American Heart Association, Inc. All rights reserved.

cAMP levels in left ventricular adult and pediatric myocardium (quantitated by ELISA). cAMP levels in left ventricular adult and pediatric myocardium (quantitated by ELISA). A, Relative cAMP levels in pediatric myocardium. B, Relative cAMP levels in adult myocardium. P values correspond to comparisons with nonfailing unless otherwise noted in the figure. F indicates failing; FT, failing treated with phosphodiesterase 3 inhibitors; and NF, nonfailing. Stephanie J. Nakano et al. Circ Heart Fail. 2015;8:57-63 Copyright © American Heart Association, Inc. All rights reserved.

Total phosphodiesterase (PDE) activity in (A) pediatric myocardium and (B) adult myocardium. Total phosphodiesterase (PDE) activity in (A) pediatric myocardium and (B) adult myocardium. F indicates failing; FT, failing treated with PDE3i; and NF, nonfailing. Stephanie J. Nakano et al. Circ Heart Fail. 2015;8:57-63 Copyright © American Heart Association, Inc. All rights reserved.

Phosphodiesterase (PDE3)–specific activity in (A) pediatric myocardium and (B) adult myocardium. Phosphodiesterase (PDE3)–specific activity in (A) pediatric myocardium and (B) adult myocardium. F indicates failing; FT, failing treated with PDE3i; and NF, nonfailing. Stephanie J. Nakano et al. Circ Heart Fail. 2015;8:57-63 Copyright © American Heart Association, Inc. All rights reserved.

Phospholamban phosphorylation at the serine 16 residue in pediatric (A and B) and adult (C and D) myocardium; representative Western blot and quantitation for each are shown. Phospholamban phosphorylation at the serine 16 residue in pediatric (A and B) and adult (C and D) myocardium; representative Western blot and quantitation for each are shown. GAPDH was used as a loading control. F indicates failing; FT, failing treated with phosphodiesterase 3 inhibitors; NF, nonfailing; PLB, phospholamban; pPLB, phospholamban phosphorylation; and Ser16, serine 16 residue. Stephanie J. Nakano et al. Circ Heart Fail. 2015;8:57-63 Copyright © American Heart Association, Inc. All rights reserved.