Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes Annette T. Hastie, PhD, Wendy C. Moore,

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Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes Annette T. Hastie, PhD, Wendy C. Moore, MD, Deborah A. Meyers, PhD, Penny L. Vestal, MS, Huashi Li, MS, Stephen P. Peters, MD, PhD, Eugene R. Bleecker, MD Journal of Allergy and Clinical Immunology Volume 125, Issue 5, Pages 1028-1036.e13 (May 2010) DOI: 10.1016/j.jaci.2010.02.008 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Sputum epithelial cell count per milliliter plotted against FEV1 % predicted (bottom) and FEV1/FVC (top). Open diamond, Nonsevere, no ICSs, FEV1 >80% predicted; closed diamond, nonsevere, ICS-treated, FEV1 >80% predicted; open triangle, nonsevere, no ICSs, FEV1 <80% predicted; closed triangle, nonsevere, ICS-treated, FEV1 <80% predicted; and closed square, severe.E1 Bronchial epithelial cells negatively associated with FEV1 % predicted (P = .03) and ratio FEV1/FVC (P = .003), suggesting epithelial damage relates to worsening lung function. Journal of Allergy and Clinical Immunology 2010 125, 1028-1036.e13DOI: (10.1016/j.jaci.2010.02.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Average Western blot band density for BDNF (top) and IL-1β (bottom) observed in sputum cell lysates for subjects grouped by <2% eosinophils + <40% neutrophils (Neither), <2% eosinophils + ≥40% neutrophils (Neu), ≥2% eosinophils + <40% neutrophils (Eos), or ≥2% eosinophils + ≥40%neutrophils (Eos+Neu). Higher levels of BDNF and IL-1β occurred in sputum cell lysates from subjects with both granulocytes elevated (Eos+Neu), although they were not significantly different. Journal of Allergy and Clinical Immunology 2010 125, 1028-1036.e13DOI: (10.1016/j.jaci.2010.02.008) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions