SECONDARY A.N.S. DISORDERS Hereditary: o        –Autosomal dominant trait o        –Familial amyloid neuropathy o        –Autosomal recessive trait o        –Familial dysautonomia: Riley-Day syndrome o        –Dopamine β hydroxylase deficiency ·         Metabolic diseases: o        –Diabetes mellitus o        –Chronic renal failure o        –Chronic liver disease o        –Alcohol induced ·         o      

SECONDARY A.N.S. DISORDERS ·         Inflammatory: o        –Guillain-Barré syndrome o        –Transverse myelitis ·         Infections: o        –Bacterial: tetanus o        –Parasitic: Chagas’ disease o        –Viral: HIV ·         Neoplasia: o        –Brain tumours, especially of third ventricle or posterior fossa o        –Paraneoplastic, to include adenocarcinomas of lung and pancreas

Cardiovascular disorders Postural hypotension Supine hypertension Lability of blood pressure Paroxysmal hypertension Tachycardia Bradycardia Fainting

Hypertension 1/3 of the UK population 1/3 Identified Adequately treated

How does High Blood Pressure develop? How is high BP maintained?

Vaso-vagal Syncope

Sexual disorders Retrograde ejaculation Ejaculatory failure Erectile failure Ejaculatory failure Retrograde ejaculation Priapism

SECONDARY A.N.S. DISORDERS Hereditary: o        –Autosomal dominant trait o        –Familial amyloid neuropathy o        –Autosomal recessive trait o        –Familial dysautonomia: Riley-Day syndrome o        –Dopamine β hydroxylase deficiency ·         Metabolic diseases: o        –Diabetes mellitus o        –Chronic renal failure o        –Chronic liver disease o        –Alcohol induced ·         o      

SECONDARY A.N.S. DISORDERS ·         Inflammatory: o        –Guillain-Barré syndrome o        –Transverse myelitis ·         Infections: o        –Bacterial: tetanus o        –Parasitic: Chagas’ disease o        –Viral: HIV ·         Neoplasia: o        –Brain tumours, especially of third ventricle or posterior fossa o        –Paraneoplastic, to include adenocarcinomas of lung and pancreas

Cardiovascular disorders Postural hypotension Supine hypertension Lability of blood pressure Paroxysmal hypertension Tachycardia Bradycardia Fainting

Hypertension 1/3 of the UK population 1/3 Identified Adequately treated

How does High Blood Pressure develop? How is high BP maintained?

Vaso-vagal Syncope

Sexual disorders Retrograde ejaculation Ejaculatory failure Erectile failure Ejaculatory failure Retrograde ejaculation Priapism