Exploring the Structure of DNA Research-Based, Interdisciplinary STEM Education (RISE)

Today’s Agenda: The Discovery of the Structure of DNA Parts of the DNA Molecule Important Bonds in DNA Double Helix Structure DNA Function Exploring Epigenetics and Methylation Seminar

Discovering the Structure of DNA: https://www.youtube.com/watch?v=1vm3od_UmFg

Part 1: Parts of the DNA Molecule

Part 2: Linking the Parts Together Through Chemical Bonds

The Phosphodiester Bond

Part 3: Exploring Hydrogen Bonding Electrostatic attraction between hydrogen atoms bonded to small, strongly electronegative atoms (N, O and F) and the lone pair electrons on these electronegative atoms.

Part 3: Hydrogen Bonding

Part 4: Double Helix

Part 5: DNA Function When does DNA replicate? Are you replicating any DNA right now? What’s important about this process?

DNA Replication:

DNA Replication: Let’s Watch http://www.youtube.com/v/4jtmOZaIvS0

Epigenetics and DNA Methylation: Do all your cells have the same DNA? Do all your cells use all their DNA? Why or why not?

Epigenetics and DNA Methylation: Differential gene expression allows different cell types to adopt different fates. Mistakes in gene regulation are associated with a variety of diseases, especially cancer.

DNA Methylation: This reaction is enzyme-mediated. DNA methylation silences genes by causing the DNA to condense.

DNA Methylation: Let’s Watch https://www.youtube.com/watch?v=29doT6Hf2MI&list=PLU1BVhkEIXAHNboZCjPi2dovL1N9EazoJ

How do we detect DNA methylation? We use CHEMISTRY!

How do we detect DNA methylation? We use CHEMISTRY!

Next: Your Seminar Find your team! Introductions and Roles. Discuss the paper, using your questions as a guide. Report out!

Structure, Function, and the Value of Visualization: https://www.youtube.com/watch?v=wJyUtbn0O5Y