XPF-ERCC1: On the Bubble

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XPF-ERCC1: On the Bubble Steven M. Shell, Walter J. Chazin Structure Volume 20, Issue 4, Pages 566-568 (April 2012) DOI: 10.1016/j.str.2012.03.004 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Two Models for the Pre-Incision Complex of Human NER Arising from Uncertainty in the XPA Binding Site (A) XPA bound to the 5′ ssDNA/dsDNA junction in the NER bubble. In this model, the binding of XPF-ERCC1 to the 5′ junction requires displacement of XPA. (B) XPA bound to the 3′ junction in the NER bubble. In this model, binding of XPA to the 3′ junction allows XPF-ERCC1 full access to the 5′ ssDNA/dsDNA substrate. This model is supported by reports indicating the XPG nuclease binds primarily to dsDNA just downstream of the 3′ ssDNA/dsDNA junction. Structure 2012 20, 566-568DOI: (10.1016/j.str.2012.03.004) Copyright © 2012 Elsevier Ltd Terms and Conditions