Supplementary material S1

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Supplementary material S1 (McFadden et al., 2005) (Fig. 1C) (Lakhani et al., 2006) Nkx2.5::Cre caspase-3loxP/loxP x caspase-7-/- Cre+/? C3+/+C7+/+ Cre-/- C3loxP/loxP C7-/- Cre+/? C3+/loxPC7+/- Cre-/- C3+/loxP C7+/- n=184 (100%) 6.25% Cre+/? C3+/+C7+/+ Cre-/- C3+/+C7+/+ 12.5% Cre+/? C3+/loxPC7+/+ Cre-/- C3+/loxPC7+/+ 6.25% Cre+/? C3loxP/loxPC7+/+ Cre-/- C3loxP/loxPC7+/+ 12.5% Cre+/? C3+/+C7+/- Cre-/- C3+/+C7+/- 75% 25% Cre+/? C3+/loxPC7+/- 25% Cre-/- C3+/loxPC7+/- n=128 (70%) 12.5% Cre+/? C3loxP/loxPC7+/- n=56 (30%) Cre-/- C3loxP/loxPC7+/- 6.25% Cre+/? C3+/+C7-/- Cre-/- C3+/+C7-/- 12.5% Cre+/? C3+/loxPC7-/- Cre-/- C3+/loxPC7-/- 6.25% Cre+/? C3loxP/loxPC7-/- Cre-/- C3loxP/loxPC7-/- Genotype n % of Cre+ (75%) % of total (100%) C3+/loxP C7+/- 36 28% 19.6% C3+/loxP C7+/+ 13 10.1% 7.07% C3+/loxP C7-/- 17 13.2% 9.24% C3+/+C7+/- 15 11.7% 8.19% C3loxP/loxP C7+/- C3+/+ C7+/+ 7 5.4% 3.78% C3+/+ C7-/- 6 4.7% 3.29% C3loxP/loxP C7+/+ 8 6.25% 4.37% C3loxP/loxP C7-/- 9 7% 4.9% Wild type Caspase-7 KO Caspase-3 KO Double KO Intercross design to obtain wild type, caspase-3KO, caspase-7KO and double mutant mice. Caspase-3 floxed mice were generated as described in Materials and Methods section and Fig.1 C and crossed with caspase-7KO mice (Lakhani et al., 2006) and their caspase-3loxP/loxP caspase-7-/- descendants were crossed with line Nkx2.5::Cre (McFadden et al., 2005). Nkx2.5::Cre; caspase-3+/loxP; caspase-7+/- mice were intercrossed to obtain the genotypes described in the figure. Expected (Mendelian) ratios are shown in italics and actual ratios are shown in parenthesis and in the table. N is the number of animals in each group included for calculations.