Comparison of the Test Characteristics of Procalcitonin to C-Reactive Protein and Leukocytosis for the Detection of Serious Bacterial Infections in Children Presenting With Fever Without Source: A Systematic Review and Meta-analysis  Chia-Hung Yo, MD, Pei-Shan Hsieh, BPH, Si-Huei Lee, MD, Jiunn-Yih Wu, MD, Shy-Shin Chang, MD, Kuang-Chau Tasi, MD, MSc, Chien-Chang Lee, MD, MSc  Annals of Emergency Medicine  Volume 60, Issue 5, Pages 591-600 (November 2012) DOI: 10.1016/j.annemergmed.2012.05.027 Copyright © 2012 American College of Emergency Physicians Terms and Conditions

Figure 1 Flow chart of study identification and inclusion. Annals of Emergency Medicine 2012 60, 591-600DOI: (10.1016/j.annemergmed.2012.05.027) Copyright © 2012 American College of Emergency Physicians Terms and Conditions

Figure 2 Plot of sensitivity and specificity for studies using procalcitonin (PCT) (A), C-reactive protein (B), or leukocyte count (C) for the detection of serious bacterial infection (SBI) among children with fever without source (FWS), together with the summary receiver operating characteristic curve (solid line) and the bivariate summary estimate (solid square), together with the corresponding 95% confidence ellipse (inner dashed line) and 95% prediction ellipse (outer dotted line). The symbol size for each study is proportional to the study size. The 95% CIs were determined on the basis of the assumption that the 2 variables follow a bivariate normal distribution. The 95% prediction region is based on independent variables, which gives a range of values around which an additional observation of the dependent variable can be expected to be located. Annals of Emergency Medicine 2012 60, 591-600DOI: (10.1016/j.annemergmed.2012.05.027) Copyright © 2012 American College of Emergency Physicians Terms and Conditions

Figure 3 Forest plot of diagnostic odds ratio for studies using PCT (A), C-reactive protein (B), or leukocyte count (C) to detect SBI among children with fever without source. Annals of Emergency Medicine 2012 60, 591-600DOI: (10.1016/j.annemergmed.2012.05.027) Copyright © 2012 American College of Emergency Physicians Terms and Conditions