LRRK2 G2019S in Families with Parkinson Disease Who Originated from Europe and the Middle East: Evidence of Two Distinct Founding Events Beginning Two.

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LRRK2 G2019S in Families with Parkinson Disease Who Originated from Europe and the Middle East: Evidence of Two Distinct Founding Events Beginning Two Millennia Ago Cyrus P. Zabetian, Carolyn M. Hutter, Dora Yearout, Alexis N. Lopez, Stewart A. Factor, Alida Griffith, Berta C. Leis, Thomas D. Bird, John G. Nutt, Donald S. Higgins, John W. Roberts, Denise M. Kay, Karen L. Edwards, Ali Samii, Haydeh Payami The American Journal of Human Genetics Volume 79, Issue 4, Pages 752-758 (October 2006) DOI: 10.1086/508025 Copyright © 2006 The American Society of Human Genetics Terms and Conditions

Figure 1 Comparison of G2019S-containing haplotypes across the LRRK2 region. Five intragenic markers (bold type) delineate two distinct haplotypes in which complete allele sharing is indicated by blue (haplotype 1) or yellow (haplotype 2) shading. For haplotype 1, significant but incomplete allele sharing is denoted by light-blue shading. For markers for which phase could not be unambiguously determined, both alleles are shown with the best call, as inferred by PHASE (Matthew Stephens' Web site) listed first (alleles of probability <.05 are in brackets). The proband of family IPD289 was homozygous for G2019S; thus, haplotypes for the paternal (p) and maternal (m) lineages are provided separately. D12S2515 (shown in italics) is unstable and was not included in haplotype analyses. The American Journal of Human Genetics 2006 79, 752-758DOI: (10.1086/508025) Copyright © 2006 The American Society of Human Genetics Terms and Conditions