1224 STEMI pts, no reperfusion, < 24 hours from onset Treatment with Enoxaparin and Tirofiban in acute MI (TETAMI) M.Cohen et al, Beth Israel Hospital, NJ 1224 STEMI pts, no reperfusion, < 24 hours from onset 4 treatment groups Enox 30 mg iv plus 1 mg/Kg sc bd alone Enox 30 mg iv plus 1 mg/Kg sc bd with Aggrastat 100 ug/Kg IV UFH 70 U/Kg plus 15 U/Kg per hour infusion UFH 70 U/Kg plus 15 U/Kg inf. with Aggrastat 100 ug/Kg IV Subgroup analysis showed protective Tirofiban trend in: Pts treated within 12 hours LV dysfunction Study underpowerd for mortality

Outcomes in TETAMI End points (all 30 days) Enoxaparin AHA 2002 review Outcomes in TETAMI End points (all 30 days) Enoxaparin Enoxaparin + tirofiban UFH UFH + tirofiban Randomized patients n=229 n=305 n=306 n=314 Death/ recurrent MI/ recurrent angina 15.4% 16.1% 17.3% 17.2% recurrent MI 8.7% 8.5% 9.2% 8.0% Treated patients n=297 n=303 n=310 Major hemorrhage 1.0% 2.0% 1.6% Hemorrh. stroke 0.0% 0.3% Cohen M. American Heart Association Scientific Sessions 2002.