Chemical structures of statins.

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Presentation transcript:

Chemical structures of statins. Chemical structures of statins. (A) Type 1 statins are characterized by a conserved lactone ring (blue), a decahydronaphthalene (Decalin) structure (black), and a butyryl side chain which is different in each statin (red). (B) Type 2 statins differ from type 1 statins due to the replacement of the butyryl side chain with a fluorophenyl group (green), and although the lactone ring structure is conserved in all statins, the decahydronaphthalene group of type 1 statins is replaced by a longer distinct side chain. Statins marked with an asterisk (*) are licensed for treatment of high cholesterol. Emma Hennessy et al. Antimicrob. Agents Chemother. 2016;60:5111-5121