Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower.

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Quantitative Proteome Analysis Reveals Increased Content of Basement Membrane Proteins in Arteries From Patients With Type 2 Diabetes Mellitus and Lower Levels Among Metformin UsersCLINICAL PERSPECTIVE by Simone A.R. Preil, Lars P. Kristensen, Hans C. Beck, Pia S. Jensen, Patricia S. Nielsen, Torben Steiniche, Marina Bjørling-Poulsen, Martin R. Larsen, Maria L. Hansen, and Lars M. Rasmussen Circ Genom Precis Med Volume 8(5):727-735 October 20, 2015 Copyright © American Heart Association, Inc. All rights reserved.

Expression of basement membrane proteins, as well as other selected proteins (as indicated on y axis), in patients without (non-DM; open columns) and with (T2DM) type 2 diabetes mellitus (black columns). Expression of basement membrane proteins, as well as other selected proteins (as indicated on y axis), in patients without (non-DM; open columns) and with (T2DM) type 2 diabetes mellitus (black columns). Moreover, results from patients with diabetes mellitus, treated without (T2DM−M) or with metformin (T2DM+M) are displayed. Results are shown as mean±SEM and P values for t tests are displayed for comparisons either of non-DM vs T2DM or T2DM–M vs T2DM+M, as indicated. Simone A.R. Preil et al. Circ Cardiovasc Genet. 2015;8:727-735 Copyright © American Heart Association, Inc. All rights reserved.

Collagen content (area fraction) and number of smooth muscle α-actin stainable cells in different layers of the internal mammary artery as revealed by histomorphometry. Collagen content (area fraction) and number of smooth muscle α-actin stainable cells in different layers of the internal mammary artery as revealed by histomorphometry. Results are shown for patients without (non-DM; open columns) and with (T2DM) type 2 diabetes mellitus (black columns). Moreover, results from patients with diabetes mellitus, treated without (T2DM–M) or with metformin (T2DM+M) are displayed. Results from different layers, as indicated, are shown as mean±SEM, and P values for t tests are displayed for comparisons of non-DM vs T2DM, as indicated. Simone A.R. Preil et al. Circ Cardiovasc Genet. 2015;8:727-735 Copyright © American Heart Association, Inc. All rights reserved.

Immunohistochemical stainings of internal mammary arteries from patient without (A and D) and with type 2 diabetes mellitus (B, C, E, and F) treated without metformin (B and E) or with metformin (C and F), stained for collagen type IV (A–C) and laminin (D–F). Immunohistochemical stainings of internal mammary arteries from patient without (A and D) and with type 2 diabetes mellitus (B, C, E, and F) treated without metformin (B and E) or with metformin (C and F), stained for collagen type IV (A–C) and laminin (D–F). Size bars=50 µm. Simone A.R. Preil et al. Circ Cardiovasc Genet. 2015;8:727-735 Copyright © American Heart Association, Inc. All rights reserved.