A B C D E F WT Simulation WT

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A B C D E F WT Simulation WT P2/P1 WT Simulation P1-P2 interval (ms) B WT Veldkamp et al. 2000. Circ. Res. 86:e91-97 C Kambouris et al. 2000. JCI. 105:1133-40 WT D Rivolta et al. 2001. JBC. 276(33):30623-30630 WT Recovery time (ms) E Wehrens et al. 2001. Circulation. 102:584-90 WT F Abriel et al. 2001. Circ. Res. 88:740-5 WT Supplemental Figure 1

Membrane potential (mV) activation availability Availability/conductance WT simulation Membrane potential (mV) B WT Chandra, Starmer and Grant. 1998. AJP. 274. H1643-54. C WT Abriel et. al. 2001. Circ. Res. 88:740-45. D WT Wehrens et. al. 2000. Circulation. 102:584-590. See also Rook et.al. 1999. Cardiovascular Res. 44. 507-17 Makita et. al. 2000. Circulation. 101:54-60. Rivolta et. al. 2001. JBC. 30623-30630. Supplemental Figure 2