Impaired Renal Vasodilation and Urinary cGMP Excretion in Dahl Salt-Sensitive Rats by Shlomoh Simchon, William Manger, Gabriele Blumberg, Jeffrey Brensilver,

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Impaired Renal Vasodilation and Urinary cGMP Excretion in Dahl Salt-Sensitive Rats by Shlomoh Simchon, William Manger, Gabriele Blumberg, Jeffrey Brensilver, and Stanley Cortell Hypertension Volume 27(3):653-657 March 1, 1996 Copyright © American Heart Association, Inc. All rights reserved.

Effect of NaCl intake on RVR (top) and cGMP excretion (bottom) in DS (back row) and DR (front row) rats. Effect of NaCl intake on RVR (top) and cGMP excretion (bottom) in DS (back row) and DR (front row) rats. Data are the control values reported in Table 2. Rats fed 0.23% and 1% NaCl diets after weaning were studied. A group of rats fed a 1% NaCl diet was changed to an 8% NaCl diet and studied after 4 days (normotensive rats) or after an additional 4 weeks (hypertensive DS rats). Vertical lines indicate SDs. *P<.01 from animals on a 0.23% NaCl diet; §P<.01 DS compared with DR rats. Shlomoh Simchon et al. Hypertension. 1996;27:653-657 Copyright © American Heart Association, Inc. All rights reserved.

Effect of NP infusion on RVR (top) and cGMP excretion (bottom) in DS (back row) and DR (front row) rats. Effect of NP infusion on RVR (top) and cGMP excretion (bottom) in DS (back row) and DR (front row) rats. Data are the infusion values reported in Table 2. Rats fed 0.23% and 1% NaCl diets from weaning were studied. A group of rats fed a 1% NaCl diet was changed to an 8% NaCl diet and studied after 4 days (normotensive rats) or after an additional 4 weeks (hypertensive DS rats). Vertical lines indicate SDs. *P<.01 from animals on a 0.23% NaCl diet; §P<.01 DS compared with DR rats. Shlomoh Simchon et al. Hypertension. 1996;27:653-657 Copyright © American Heart Association, Inc. All rights reserved.

RVR as a function of cGMP excretion in DR (•) and DS (x) rats on various NaCl diets and also after NP infusions. RVR as a function of cGMP excretion in DR (•) and DS (x) rats on various NaCl diets and also after NP infusions. Shlomoh Simchon et al. Hypertension. 1996;27:653-657 Copyright © American Heart Association, Inc. All rights reserved.