Attenuation of cardiac remodeling by indole-3-carbinol in mice is associated with improved energy metabolism  Wei Deng, Li Wei, Jing Zong, Zhouyan Bian, Heng Zhou, Rui Zhang, Qizhu Tang  International Journal of Cardiology  Volume 172, Issue 3, Pages e531-e533 (April 2014) DOI: 10.1016/j.ijcard.2014.01.066 Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 1 I3C attenuates cardiac remodeling and dysfunction and activates myocardial energy metabolism-related substrates induced by pressure overload in WT mice. A. General data from four groups of mice at 8weeks after AB or sham surgery (n=9). B. Echocardiography results from four groups of mice at 8 weeks after AB or sham surgery (n=7). C. Real-time PCR analysis of the mRNA expression of PPARα, PGC-1α, CPT-1, MCAD, LCAD, CD36, FABP3 and Glut4 in the myocardium obtained from indicated groups (n=6). Values represent means±SEM. #p<0. 05 and ##p<0.01 compared with the Veh-sham group; *p<0.05 and **p<0.01 compared with the Veh-AB group. International Journal of Cardiology 2014 172, e531-e533DOI: (10.1016/j.ijcard.2014.01.066) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions

Fig. 2 I3C exhibits no protective effects on cardiac remodeling and heart function and loses its beneficial effect on energy metabolism-related substrates induced by pressure overload in KO mice. A. General data from four groups of mice at 4weeks after AB or sham surgery (n=9). B. Echocardiography results from four groups of mice at 4 weeks after AB or sham surgery (n=8). C. Real-time PCR analysis of the mRNA expression of PPARα, PGC-1α, CPT-1, MCAD, LCAD, CD36, FABP3 and Glut4 in the myocardium obtained from indicated groups (n=6). Values represent means±SEM. #p<0. 05 and ##p<0.01 compared with the Veh-sham group; *p<0.05 and **p<0.01 compared with the Veh-AB group. International Journal of Cardiology 2014 172, e531-e533DOI: (10.1016/j.ijcard.2014.01.066) Copyright © 2014 Elsevier Ireland Ltd Terms and Conditions