IDH1 mutant glioma cells are sensitive to TMZ

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Date of download: 6/21/2016 Copyright © 2016 American Medical Association. All rights reserved. From: Advances in Translational Research in Neuro-oncology.

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Presentation transcript:

IDH1 mutant glioma cells are sensitive to TMZ IDH1 mutant glioma cells are sensitive to TMZ. A, TMZ dose-response curves of U87 MG and U251 MG cells with IDH1 mutation for 96 hours (n = 3). IDH1 mutant glioma cells are sensitive to TMZ. A, TMZ dose-response curves of U87 MG and U251 MG cells with IDH1 mutation for 96 hours (n = 3). B, Annexin-V apoptosis analysis of IDH1 mutant cell with TMZ treatment. C, Cell-cycle analysis of IDH1 mutant cells with TMZ treatment (left). The overview of cell-cycle progression with clear G2–M arrest (right). D, DNA fragmentation test for IDH1 mutant cells treated with TMZ. Yanxin Lu et al. Cancer Res 2017;77:1709-1718 ©2017 by American Association for Cancer Research