Homework #3 is due 11/19 Bonus #2 is posted.

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Presentation transcript:

Homework #3 is due 11/19 Bonus #2 is posted

The Cell Cycle Fig 2.9

Mitosis: A DNA Perspective

Mitosis plays a role in: Growth and Development Repair and Turnover of Cells Reproduction Asexual

start of mitosis Fig 2.10

A basic look at mitosis The Mitotic Spindle (micro- tubules) Sister Chromatids

Mitosis is tightly regulated: checkpoints

Cell division is regulated by both positive and negative signals Cell division is regulated by both positive and negative signals. Positive signals start the process of cell division. Negative signals inhibit cell division.

2 proteins, Cyclin and Cdk, control entry into mitosis

2 proteins, Cyclin and Cdk, control entry into mitosis.

Balance between Longevity and Health Fig. 3 TRENDS in Ecology and Evolution Vol 21 pg 47

Mutations

Cancer: Cell Division Gone Wrong

Normal Mammalian Cells Have Contact Inhibition

Cancer Cells Do Not Have Contact Inhibition

Tumors in a Liver normal tumors

Cancer: is the loss of control over cell division. Tumors are normal cells that are dividing inappropriately. They stop performing their “normal” function, and are dividing repeatedly.

A cell becomes cancerous when there are incorrect positive AND negative signals.

GO! STOP! cancer similar to Fig 15.36

Multiple mutations are required for cancer to occur

Normal Cells Cancer Cells

Benign versus Malignant cancer

How do these mutations arrise?

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