The cell cycle. The cell cycle. The four phases of the mitotic cell division cycle are indicated in the inner circle, including mitosis (M phase), the.

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The cell cycle. The cell cycle. The four phases of the mitotic cell division cycle are indicated in the inner circle, including mitosis (M phase), the cellular DNA synthesis (S) phase, and their separation by two gap (G) phases, the first (G1) between M and S phases and the second (G2) between S and M phases. The levels of total CDK activity are lowest in early G1 phase and progressively increase under the agency of different cyclin–CDK complexes, reaching maximal net CDK activity as cells enter mitosis. States of RB phosphorylation (P) throughout the cell cycle are schematized. RB is dephosphorylated in M phase (green arrow) and progressively rephosphorylated in G1, first by cyclin D–dependent CDK4/6 and later by cyclin E–dependent CDK2. RB becomes fully phosphorylated in late G1 (red arrow), resulting in inactivation of its proliferation-suppressive function and triggering the cell's subsequent entry into S phase. The point in the cell cycle (sometimes called “the restriction point”; red arrow) at which RB becomes fully phosphorylated temporally corresponds to a late G1 phase transition when cells lose their marked dependency on extracellular mitogens and commit to enter S phase and complete the cycle. During the S and G2 phases, RB phosphorylation is maintained by the progressive activation of other CDKs, including cyclin A–CDK2 and cyclins A/B–CDK1. Degradation of cyclins A and B in mitosis results in the collapse of CDK activity and restores the G1 state. INK4 proteins (the prototype p16INK4A is shown) specifically inhibit the cyclin D–dependent kinases to inhibit RB phosphorylation and arrest cells in G1 phase. Arrested cells can return to a noncycling but reversible quiescent state (G0) after mitogen withdrawal in which D-type cyclins are usually degraded or, in response to particular stress conditions, can undergo durable cell-cycle arrest (senescence). Quiescent cells restimulated with mitogens restore cyclin D synthesis and re-enter the cell cycle in early G1, whereas senescent cells are refractory to mitogen restimulation and resist oncogenic challenge. Asynchronously dividing cells maintain mitogen-dependent cyclin D synthesis and have a contracted G1 phase when compared with quiescent cells re-entering the division cycle (for pertinent detailed reviews, see refs. 4, 16, 41, 65). Charles J. Sherr et al. Cancer Discov 2016;6:353-367 ©2016 by American Association for Cancer Research