Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women Xuemei Sui, MD, MPH, PhD, Mark A. Sarzynski,

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Longitudinal Patterns of Cardiorespiratory Fitness Predict the Development of Hypertension Among Men and Women Xuemei Sui, MD, MPH, PhD, Mark A. Sarzynski, PhD, Duck-chul Lee, PhD, Carl J. Lavie, MD, Jiajia Zhang, PhD, Peter F. Kokkinos, PhD, Jonathan Payne, MS, Steven N. Blair, PED The American Journal of Medicine Volume 130, Issue 4, Pages 469-476.e2 (April 2017) DOI: 10.1016/j.amjmed.2016.11.017 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Multivariable* adjusted ORs and 95% CIs of incidence hypertension by fitness change groups across baseline cardiorespiratory fitness levels (low, middle, and upper tertiles). *Adjusted by baseline age, sex, resting systolic blood pressure, current smoker, heavy alcohol intake, physically inactive, BMI, diabetes, hypercholesterolemia, parental history of hypertension, follow-up duration, and number of follow-up visits. Decreasing is the referent. CI = confidence interval; BMI = body mass index; OR = odds ratio. The American Journal of Medicine 2017 130, 469-476.e2DOI: (10.1016/j.amjmed.2016.11.017) Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 2 Multivariable* adjusted ORs and 95% CIs of incidence hypertension by fitness change groups across baseline BMI groups. *Adjusted by baseline age, sex, resting systolic blood pressure, current smoker, heavy alcohol intake, physically inactive, diabetes, hypercholesterolemia, parental history of hypertension, follow-up duration, and number of follow-up visits. Decreasing is the referent. CI = confidence interval; BMI = body mass index; OR = odds ratio. The American Journal of Medicine 2017 130, 469-476.e2DOI: (10.1016/j.amjmed.2016.11.017) Copyright © 2016 Elsevier Inc. Terms and Conditions

Supplementary Figure Example graphs that illustrate the 6 longitudinal cardiorespiratory fitness patterns. Per change, yearly percentage of cardiorespiratory fitness (in metabolic equivalents) change. The American Journal of Medicine 2017 130, 469-476.e2DOI: (10.1016/j.amjmed.2016.11.017) Copyright © 2016 Elsevier Inc. Terms and Conditions