Voltage-gated ion channels

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Presentation transcript:

Voltage-gated ion channels

Purifyinf ryanodine receptors

Purifying ryanodine receptors

Recording ryanodine receptors in planar lipid bilayers

Ryanodine receptor single channel currents

Ryanodine receptor single channel currents

Ryanodine receptor single channel currents

Regulation of EC coupling by adrenergic signaling -- “fight or flight”

RyR2 macromolecular complex

RyR macromolecular complexes are leucine/isoleucine zippers held together by leucine/isoleucine zippers

RyR2/calcium release channel phosphorylated by addition of cAMP alone

PKA phosphorylation activates RyR2 and induces subconductance states

Dependence of ryanodine receptor conductance on luminal calcium concentration

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