Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring Susanne Hansen, MSc, Marin Strøm, PhD, Ekaterina Maslova,

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Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring Susanne Hansen, MSc, Marin Strøm, PhD, Ekaterina Maslova, ScD, Ronald Dahl, MD, DMSc, Hans Jürgen Hoffmann, PhD, Dorte Rytter, PhD, Bodil Hammer Bech, MD, PhD, Tine Brink Henriksen, MD, PhD, Charlotta Granström, MSc, Thorhallur I. Halldorsson, PhD, Jorge E. Chavarro, MD, ScD, Allan Linneberg, MD, PhD, Sjurdur F. Olsen, MD, DMSc Journal of Allergy and Clinical Immunology Volume 139, Issue 1, Pages 104-111.e4 (January 2017) DOI: 10.1016/j.jaci.2016.02.042 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Participation flow in the Aarhus Trial. Journal of Allergy and Clinical Immunology 2017 139, 104-111.e4DOI: (10.1016/j.jaci.2016.02.042) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Twenty-four-year follow-up of offspring from an RCT (n = 396) with fish oil supplementation in pregnancy. Kaplan-Meier survival curves show occurrences of asthma discharge diagnoses in the national patient register (A) and asthma (B) and allergic rhinitis medication use (C), respectively, in the national prescription registry stratified by randomization group. Journal of Allergy and Clinical Immunology 2017 139, 104-111.e4DOI: (10.1016/j.jaci.2016.02.042) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 ORs, ratios between geometric means, and mean differences with 95% CIs of self-reported (A) and clinical (B and C) outcomes comparing offspring in the fish oil group with those in the olive oil group. Journal of Allergy and Clinical Immunology 2017 139, 104-111.e4DOI: (10.1016/j.jaci.2016.02.042) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions