Prediction of Cardiovascular Disease by the Framingham‐REGICOR Equation in the High‐Risk PREDIMED Cohort: Impact of the Mediterranean Diet Across Different.

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Prediction of Cardiovascular Disease by the Framingham‐REGICOR Equation in the High‐Risk PREDIMED Cohort: Impact of the Mediterranean Diet Across Different Risk Strata by Antonio J. Amor, Mercè Serra‐Mir, Miguel A. Martínez‐González, Dolores Corella, Jordi Salas‐Salvadó, Montserrat Fitó, Ramón Estruch, Lluis Serra‐Majem, Fernando Arós, Nancy Babio, Emilio Ros, Emilio Ortega, and J Am Heart Assoc Volume 6(3):e004803 March 13, 2017 © 2017 Antonio J. Amor et al.

Flow‐chart of PREDIMED participants using Framingham‐REGICOR strategy. Flow‐chart of PREDIMED participants using Framingham‐REGICOR strategy. CVR indicates cardiovascular risk; LDL‐C, low‐density lipoprotein cholesterol. Antonio J. Amor et al. J Am Heart Assoc 2017;6:e004803 © 2017 Antonio J. Amor et al.

Cardiovascular risk estimated by Framingham‐REGICOR strategy in population aged 55 to 75 years in the total cohort (n=5966) (A), among women (n=3375) (B), and among men (n=2591) (C). Cardiovascular risk estimated by Framingham‐REGICOR strategy in population aged 55 to 75 years in the total cohort (n=5966) (A), among women (n=3375) (B), and among men (n=2591) (C). Data are shown as number and percentage. Antonio J. Amor et al. J Am Heart Assoc 2017;6:e004803 © 2017 Antonio J. Amor et al.

Hazards ratios of cardiovascular disease events of merged MedDiet/EVOO and MedDiet/nuts across estimated cardiovascular risk categories by the Framingham‐REGICOR strategy. Hazards ratios of cardiovascular disease events of merged MedDiet/EVOO and MedDiet/nuts across estimated cardiovascular risk categories by the Framingham‐REGICOR strategy. Unadjusted (A) and fully adjusted (B) models for major cardiovascular events (acute myocardial infarction, stroke, and cardiovascular death). Unadjusted (C) and fully adjusted (D) models for expanded major cardiovascular events (with addition of cardiac revascularization and peripheral arterial disease). B and D, Additionally adjusted for baseline adherence to the MedDiet, educational level, body mass index, triglycerides, treated hypertension, dyslipidemia, statin treatment, and physical activity. P values less than or equal to a false discovery rate q=0.024 show significant results (see Statistical Analyses). EVOO indicates extra‐virgin olive oil; HR, hazard ratio; MedDiet, Mediterranean diet. Antonio J. Amor et al. J Am Heart Assoc 2017;6:e004803 © 2017 Antonio J. Amor et al.