Effect of Obesity on In-Hospital Mortality in Patients with Cardiogenic Shock Complicating AMI Obesity is paradoxically associated with favorable mortality outcomes in acute myocardial infarction (AMI). Association between obesity & in-hospital mortality among patients with cardiogenic shock (CS) complicating AMI (N=290,894) was retrospectively studied. National Inpatient Sample database from the 2004 - 13 Obese patients (n=25,835, 8.9%) had more cardiovascular (CV) comorbidities & more likely to receive revascularization than non-obese patients (73.0% vs 63.4%). Obese patients had higher prevalence of CV risks including dyslipidemia, previous MI, hypertension, and previous PCI. Obese patients had lower risk-adjusted in-hospital mortality rate (28.2% vs 36.5%, p<0.001). Obese patients in this analysis were younger, more likely to receive revascularization, which may explain the observed “obesity paradox.” Chatterjee K et al. Am J Cardiol. 2017. NPS-043-17