Anti-CD40 and CpG induce activation of T cells in draining lymph nodes

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Anti-CD40 and CpG induce activation of T cells in draining lymph nodes. Anti-CD40 and CpG induce activation of T cells in draining lymph nodes. C57BL/6 mice (three mice per group) were injected s.c. into the left side of the abdomen with 2 × 106 B78 cells (day 0). On day 7, the mice were injected i.p. with anti-CD40, and on day 10, they received CpG IT. Control mice received PBS. On day 11, left inguinal lymph nodes were collected, pooled, and stained with anti-CD4, anti-CD8, and Abs against T cell activation markers. Results are shown as histograms of viable lymph node cells gated on either CD4+ or CD8+ cells. Gray areas show staining with specific Abs, and white areas are isotype controls. Numbers above indicate percentage of positive cells, and numbers below indicate mean fluorescence intensity. Alexander L. Rakhmilevich et al. J Immunol 2017;198:1575-1584 Copyright © 2017 by The American Association of Immunologists, Inc.